TBPA_HAEIN
ID TBPA_HAEIN Reviewed; 912 AA.
AC P44970;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Transferrin-binding protein A {ECO:0000305};
DE Short=TbpA {ECO:0000305};
DE AltName: Full=Transferrin-binding protein 1;
DE Flags: Precursor;
GN Name=tbpA {ECO:0000305}; Synonyms=tbp1 {ECO:0000303|PubMed:7542800};
GN OrderedLocusNames=HI_0994;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Haemophilus acquires iron by extracting it from serum
CC transferrin (TF) in its human host. Acts as a transferrin receptor and
CC is required for transferrin utilization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000250|UniProtKB:Q9K0U9}.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC {ECO:0000305}.
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DR EMBL; L42023; AAC22656.1; -; Genomic_DNA.
DR PIR; C64107; C64107.
DR RefSeq; NP_439157.1; NC_000907.1.
DR RefSeq; WP_005693337.1; NC_000907.1.
DR AlphaFoldDB; P44970; -.
DR SMR; P44970; -.
DR STRING; 71421.HI_0994; -.
DR TCDB; 1.B.14.2.12; the outer membrane receptor (omr) family.
DR EnsemblBacteria; AAC22656; AAC22656; HI_0994.
DR KEGG; hin:HI_0994; -.
DR PATRIC; fig|71421.8.peg.1037; -.
DR eggNOG; COG1629; Bacteria.
DR eggNOG; COG4771; Bacteria.
DR HOGENOM; CLU_008287_19_0_6; -.
DR OMA; PSFAEMY; -.
DR PhylomeDB; P44970; -.
DR BioCyc; HINF71421:G1GJ1-1036-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031230; C:intrinsic component of cell outer membrane; IBA:GO_Central.
DR GO; GO:0015091; F:ferric iron transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR Gene3D; 2.170.130.10; -; 1.
DR Gene3D; 2.40.170.20; -; 1.
DR InterPro; IPR039426; BtuB-like.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR037066; Plug_dom_sf.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR010916; TonB_box_CS.
DR InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR InterPro; IPR010948; TonB_lacto/transferrin_rcpt.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR InterPro; IPR010917; TonB_rcpt_CS.
DR PANTHER; PTHR30069; PTHR30069; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR TIGRFAMs; TIGR01776; TonB-tbp-lbp; 1.
DR PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
DR PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Membrane; Receptor; Reference proteome; Signal;
KW TonB box; Transmembrane; Transmembrane beta strand; Virulence.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..912
FT /note="Transferrin-binding protein A"
FT /id="PRO_0000034776"
FT MOTIF 50..57
FT /note="TonB box"
FT MOTIF 895..912
FT /note="TonB C-terminal box"
SQ SEQUENCE 912 AA; 103234 MW; 294C08991A652CC2 CRC64;
MTKKPYFRLS IISCLLISCY VKAETQSIKD TKEAISSEVD TQSTEDSELE TISVTAEKVR
DRKDNEVTGL GKIIKTSESI SREQVLNIRD LTRYDPGISV VEQGRGASSG YSIRGMDRNR
VALLVDGLPQ TQSYVVQSPL VARSGYSGTG AINEIEYENV KAVEISKGGS SSEYGNGALA
GSVTFQSKSA ADILEGDKSW GIQTKNAYSS KNKGFTHSLA VAGKQGGFEG LAIYTQRNSI
ETQVHKDALK GVQSYNRLIA KPENQSAYFV MEDECPKGYD ECIPSAKPPA ILSTKKETVS
VSDYTGANRI KPNPMKYESQ SWFLRGGYHF SEQHYIGGIF EFTQQKFDIR DMTFPAYLSP
TEKGDLANRP FYPKQDYGAY QHIEDGRGVK YASGLYFDEH HRKQRVGIEY IYENKNKAGI
IDKAVLSANQ QNIILDSYMR HTHCSLYPNP SKNCRPTLDK PYSYYRSDRN VYKEKHNMLQ
LNLEKKIQQN WLTHQIVFNL GFDDFTSALQ HKDYLTRRVI ATADSISDKT GKTRRNGLRE
YPYLYPKPKP YFAGEDHCNY QGSSSNYRDC KVRLIKGKNY YFAARNNMAL GKYVDLGLGI
RYDVSRTKAN ESTISVGKFK NFSWNTGIVI KPTEWLDLSY RLSTGFRNPS FAEMYGWRYG
GKNDEVYVGK FKPETSRNQE FGLALKGDFG NIEISHFSNA YRNLIAFAEE LSKNGTGKGN
YGYHNAQNAK LVGVNITAQL DFNGLWKRIP YGWYATFAYN RVKVKDQKIN AGLASVSSYL
FDAIQPSRYI IGLGYDHISN TWGVNATFTQ SKAKSQNELL GKRALGNNSR DVKSTRKLTR
AWHILDVSGY YMANKNIMLR LGIYNLFNYR YVTWEAVRQT AQGAVNQHQN VGNYTRYAAS
GRNYTLTLEM KF
