TBPB_HAEI8
ID TBPB_HAEI8 Reviewed; 630 AA.
AC Q4QLR5;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Transferrin-binding protein B {ECO:0000303|PubMed:28620585};
DE Short=TbpB {ECO:0000303|PubMed:28620585};
DE AltName: Full=Transferrin-binding protein 2 {ECO:0000303|PubMed:15968074};
DE Flags: Precursor;
GN Name=tbpB {ECO:0000303|PubMed:28620585};
GN Synonyms=tbp2 {ECO:0000303|PubMed:15968074}; OrderedLocusNames=NTHI1169;
OS Haemophilus influenzae (strain 86-028NP).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=281310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=86-028NP;
RX PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA Munson R.S. Jr.;
RT "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL J. Bacteriol. 187:4627-4636(2005).
RN [2]
RP TRANSFERRIN-BINDING, AND SUBCELLULAR LOCATION.
RC STRAIN=86-028NP;
RX PubMed=28620585; DOI=10.3389/fcimb.2017.00207;
RA Hooda Y., Lai C.C.L., Moraes T.F.;
RT "Identification of a Large Family of Slam-Dependent Surface Lipoproteins in
RT Gram-Negative Bacteria.";
RL Front. Cell. Infect. Microbiol. 7:207-207(2017).
CC -!- FUNCTION: Haemophilus acquires iron by extracting it from serum
CC transferrin (TF) in its human host. Acts as a transferrin receptor and
CC is required for transferrin utilization. {ECO:0000305|PubMed:28620585}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00303, ECO:0000269|PubMed:28620585}; Lipid-anchor
CC {ECO:0000255|PROSITE-ProRule:PRU00303}. Cell surface
CC {ECO:0000269|PubMed:28620585}. Note=When expressed in E.coli.
CC {ECO:0000269|PubMed:28620585}.
CC -!- SIMILARITY: Belongs to the TbpB family. {ECO:0000305}.
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DR EMBL; CP000057; AAX88032.1; -; Genomic_DNA.
DR RefSeq; WP_011272339.1; NC_007146.2.
DR AlphaFoldDB; Q4QLR5; -.
DR SMR; Q4QLR5; -.
DR EnsemblBacteria; AAX88032; AAX88032; NTHI1169.
DR KEGG; hit:NTHI1169; -.
DR HOGENOM; CLU_024250_0_0_6; -.
DR OMA; GWFAYPG; -.
DR OrthoDB; 211030at2; -.
DR Proteomes; UP000002525; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR Gene3D; 2.40.128.240; -; 1.
DR InterPro; IPR011250; OMP/PagP_b-brl.
DR InterPro; IPR001677; TbpB_B_D.
DR InterPro; IPR035316; TbpB_C-lobe.
DR InterPro; IPR038197; TbpB_C-lobe_sf.
DR InterPro; IPR035313; TbpB_N-lobe.
DR Pfam; PF17484; TbpB_A; 1.
DR Pfam; PF01298; TbpB_B_D; 2.
DR Pfam; PF17483; TbpB_C; 1.
DR SUPFAM; SSF56925; SSF56925; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Lipoprotein; Membrane; Palmitate; Signal; Virulence.
FT SIGNAL 1..17
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 18..630
FT /note="Transferrin-binding protein B"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT /id="PRO_0000450811"
FT REGION 26..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 18
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 18
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ SEQUENCE 630 AA; 69327 MW; 9FE74DC161797AF6 CRC64;
MKSVPLITGG LSFLLSACSG GGGSFDVDDV SNPSSSKPRY QDDTSSSRTK SNLEKLSIPS
LGGGMKLVAQ NLSGNKEPSF LNENGYISYF SSPSTIEDDV KNVKTENKIH TNPIGLEPNR
ALQDPNLQKY VYSGLYYIEN WKDFSKLATE KKAYSGHYGY AFYYGNKTAT DLPVSGVATY
KGTWDFITAT KYGQNYSLFS NARGQAYFRR SATRGDIDLE NNSKNGDIGL ISEFSADFGT
KKLTGQLSYT KRKTDIQQYE KEKLYDIDAH IYSNRFRGKV TPTKSTSDEH PFTSEGTLEG
GFYGPNAEEL GGKFLARDKR VFGVFSAKET PETEKEKLSK ETLIDGKLIT FSTKTADATT
STTASTTADV KTDEKNFTTK DISSFGEADY LLIDNYPVPL FPEGDTDDFV TSKHHDIGNK
TYKVEACCKN LSYVKFGMYY EDKEKKNTNQ TGQYHQFLLG LRTPSSQIPV TGNVKYLGSW
FGYIGDDKTS YSTTGNKQQD KNAPAEFDVN FDNKTLTGKL KRADSQNTVF NIEATFKNGS
NAFEGKATAN VVIDPKNTQA TSKVNFTTTV NGAFYGPHAT ELGGYFTYNG NNPTATNSES
SSTVPSPPNS PNARAAVVFG AKRQVEKTNK
