TBPL1_BOVIN
ID TBPL1_BOVIN Reviewed; 186 AA.
AC Q32LB1;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=TATA box-binding protein-like 1;
DE Short=TBP-like 1;
DE AltName: Full=TATA box-binding protein-related factor 2;
DE Short=TBP-related factor 2;
DE AltName: Full=TBP-like factor;
DE AltName: Full=TBP-related protein;
GN Name=TBPL1; Synonyms=TLF, TLP, TRF2, TRP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of a specialized transcription system that mediates the
CC transcription of most ribosomal proteins through the 5'-TCT-3' motif
CC which is a core promoter element at these genes. Seems to also mediate
CC the transcription of NF1. Does not bind the TATA box (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Binds TFIIA and TFIIB. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC109666; AAI09667.1; -; mRNA.
DR RefSeq; NP_001069758.1; NM_001076290.2.
DR AlphaFoldDB; Q32LB1; -.
DR SMR; Q32LB1; -.
DR STRING; 9913.ENSBTAP00000046701; -.
DR PaxDb; Q32LB1; -.
DR Ensembl; ENSBTAT00000049877; ENSBTAP00000046701; ENSBTAG00000035370.
DR GeneID; 613818; -.
DR KEGG; bta:613818; -.
DR CTD; 9519; -.
DR VEuPathDB; HostDB:ENSBTAG00000035370; -.
DR VGNC; VGNC:35660; TBPL1.
DR eggNOG; KOG3302; Eukaryota.
DR GeneTree; ENSGT00940000155712; -.
DR HOGENOM; CLU_060161_4_1_1; -.
DR InParanoid; Q32LB1; -.
DR OMA; NCEYEPE; -.
DR OrthoDB; 1219067at2759; -.
DR TreeFam; TF300102; -.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000035370; Expressed in oocyte and 105 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0005672; C:transcription factor TFIIA complex; IEA:Ensembl.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:Ensembl.
DR GO; GO:0001675; P:acrosome assembly; IEA:Ensembl.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:Ensembl.
DR GO; GO:0007289; P:spermatid nucleus differentiation; IEA:Ensembl.
DR CDD; cd04517; TLF; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR015445; TBP-like.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..186
FT /note="TATA box-binding protein-like 1"
FT /id="PRO_0000293548"
SQ SEQUENCE 186 AA; 20887 MW; 2CDD9F5E7BDDE63F CRC64;
MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK LRKPRITATI
WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF KVVNVLAVCN MPFEIRLPEF
TKNNRPHASY EPELHPAVCY RIKSLRATLQ IFSTGSITVT GPNVKAVATA VEQIYPFVFE
SRKEIL
