ID   TBPL1_DANRE             Reviewed;         186 AA.
AC   Q5U385; Q71H63;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=TATA box-binding protein-like 1 {ECO:0000250|UniProtKB:P62380};
DE            Short=TBP-like 1 {ECO:0000250|UniProtKB:P62380};
DE   AltName: Full=TATA box-binding protein-related factor 2 {ECO:0000250|UniProtKB:P62380};
DE            Short=TBP-related factor 2 {ECO:0000250|UniProtKB:P62380};
DE   AltName: Full=TBP-like factor {ECO:0000312|EMBL:AAQ07595.1};
GN   Name=tbpl1 {ECO:0000312|ZFIN:ZDB-GENE-040520-2};
GN   Synonyms=tlf {ECO:0000312|EMBL:AAQ07595.1},
GN   tlp {ECO:0000312|ZFIN:ZDB-GENE-040520-2},
GN   trf2 {ECO:0000312|ZFIN:ZDB-GENE-040520-2},
GN   trp {ECO:0000312|ZFIN:ZDB-GENE-040520-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Gonad;
RX   PubMed=11250159; DOI=10.1016/s0960-9822(01)00076-8;
RA   Mueller F., Lakatos L., Dantonel J.-C., Straehle U., Tora L.;
RT   "TBP is not universally required for zygotic RNA polymerase II
RT   transcription in zebrafish.";
RL   Curr. Biol. 11:282-287(2001).
RN   [2] {ECO:0000312|EMBL:AAQ07595.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of a specialized transcription system that mediates the
CC       transcription of most ribosomal proteins through the 5'-TCT-3' motif
CC       which is a core promoter element at these genes. Seems to also mediate
CC       the transcription of NF1. Does not bind the TATA box (By similarity).
CC       Members of the TBP family are differentially required to regulate
CC       transcription and development during early embryogenesis. {ECO:0000250,
CC       ECO:0000269|PubMed:11250159}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6SJ96}. Nucleus
CC       {ECO:0000250|UniProtKB:Q6SJ96}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255}.
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DR   EMBL; AF503448; AAQ07595.1; -; mRNA.
DR   EMBL; BC085661; AAH85661.1; -; mRNA.
DR   RefSeq; NP_991285.1; NM_205722.1.
DR   RefSeq; XP_005162362.1; XM_005162305.2.
DR   AlphaFoldDB; Q5U385; -.
DR   SMR; Q5U385; -.
DR   STRING; 7955.ENSDARP00000053533; -.
DR   PaxDb; Q5U385; -.
DR   Ensembl; ENSDART00000053534; ENSDARP00000053533; ENSDARG00000036868.
DR   Ensembl; ENSDART00000160748; ENSDARP00000134538; ENSDARG00000036868.
DR   GeneID; 403035; -.
DR   KEGG; dre:403035; -.
DR   CTD; 9519; -.
DR   ZFIN; ZDB-GENE-040520-2; tbpl1.
DR   eggNOG; KOG3302; Eukaryota.
DR   GeneTree; ENSGT00940000155712; -.
DR   HOGENOM; CLU_060161_4_1_1; -.
DR   InParanoid; Q5U385; -.
DR   OMA; NCEYEPE; -.
DR   OrthoDB; 1219067at2759; -.
DR   PhylomeDB; Q5U385; -.
DR   TreeFam; TF300102; -.
DR   PRO; PR:Q5U385; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000036868; Expressed in mature ovarian follicle and 28 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:UniProtKB.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IMP:UniProtKB.
DR   CDD; cd04517; TLF; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR015445; TBP-like.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..186
FT                   /note="TATA box-binding protein-like 1"
FT                   /id="PRO_0000351152"
FT   CONFLICT        81
FT                   /note="A -> S (in Ref. 1; AAQ07595)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   186 AA;  20761 MW;  84CBAA76AD3AC966 CRC64;
     MEPSNDVALD IIVTNVVSVF RTRCHLNLRT IGLEGTNVIY KPEVGKVLMK LRKPRITASI
     WSSGKIICTG ATSEEEAKLG ARRLARCLQK MGFKVRFSDF KVVNVLAVCS MPFQIRLIEF
     TKNNRPIASY EPELHPAASY RIKNLRSTVQ VFSTGNITVT GPNVQSVASA VEEIYPLLFE
     CRKTLS