ID   TBPL1_ENTHI             Reviewed;         216 AA.
AC   A7UFC2; C4M2T3;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=TATA-box-binding protein-like 1;
DE            Short=EhTRF1;
GN   Name=trf1; ORFNames=EHI_077240;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=20026212; DOI=10.1016/j.pep.2009.12.007;
RA   Castanon-Sanchez C.A., Luna-Arias J.P., de Dios-Bravo M.G.,
RA   Herrera-Aguirre M.E., Olivares-Trejo J.J., Orozco E., Hernandez J.M.;
RT   "Entamoeba histolytica: a unicellular organism containing two active genes
RT   encoding for members of the TBP family.";
RL   Protein Expr. Purif. 70:48-59(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 30459 / HM-1:IMSS;
RX   PubMed=15729342; DOI=10.1038/nature03291;
RA   Loftus B.J., Anderson I., Davies R., Alsmark U.C., Samuelson J., Amedeo P.,
RA   Roncaglia P., Berriman M., Hirt R.P., Mann B.J., Nozaki T., Suh B., Pop M.,
RA   Duchene M., Ackers J., Tannich E., Leippe M., Hofer M., Bruchhaus I.,
RA   Willhoeft U., Bhattacharya A., Chillingworth T., Churcher C.M., Hance Z.,
RA   Harris B., Harris D., Jagels K., Moule S., Mungall K.L., Ormond D.,
RA   Squares R., Whitehead S., Quail M.A., Rabbinowitsch E., Norbertczak H.,
RA   Price C., Wang Z., Guillen N., Gilchrist C., Stroup S.E., Bhattacharya S.,
RA   Lohia A., Foster P.G., Sicheritz-Ponten T., Weber C., Singh U.,
RA   Mukherjee C., El-Sayed N.M.A., Petri W.A., Clark C.G., Embley T.M.,
RA   Barrell B.G., Fraser C.M., Hall N.;
RT   "The genome of the protist parasite Entamoeba histolytica.";
RL   Nature 433:865-868(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 30459 / HM-1:IMSS;
RA   Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: TATA box-binding transcription factor. Members of the TBP
CC       family are differentially required to regulate transcription and
CC       development during early embryogenesis. {ECO:0000269|PubMed:20026212}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; EU052294; ABS89251.1; -; Genomic_DNA.
DR   EMBL; DS571229; EAL49549.1; -; Genomic_DNA.
DR   RefSeq; XP_654935.1; XM_649843.1.
DR   AlphaFoldDB; A7UFC2; -.
DR   SMR; A7UFC2; -.
DR   STRING; 5759.rna_EHI_077240-1; -.
DR   GeneID; 3409255; -.
DR   KEGG; ehi:EHI_077240; -.
DR   VEuPathDB; AmoebaDB:EHI5A_011690; -.
DR   VEuPathDB; AmoebaDB:EHI7A_077400; -.
DR   VEuPathDB; AmoebaDB:EHI8A_114190; -.
DR   VEuPathDB; AmoebaDB:EHI_077240; -.
DR   VEuPathDB; AmoebaDB:KM1_014200; -.
DR   eggNOG; KOG3302; Eukaryota.
DR   InParanoid; A7UFC2; -.
DR   OMA; NCEYEPE; -.
DR   Proteomes; UP000001926; Partially assembled WGS sequence.
DR   GO; GO:0005669; C:transcription factor TFIID complex; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IDA:UniProtKB.
DR   CDD; cd04516; TBP_eukaryotes; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   InterPro; IPR033710; TBP_eukaryotic.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..216
FT                   /note="TATA-box-binding protein-like 1"
FT                   /id="PRO_0000394123"
FT   REPEAT          38..121
FT                   /note="1"
FT   REPEAT          126..210
FT                   /note="2"
SQ   SEQUENCE   216 AA;  24184 MW;  404804724BECB8F0 CRC64;
     MSSQSSPISL TNNDLEISSN NNKPIIKQLP VPTNEIEKPV IQNIVATVEL DCTINLQDVV
     RRVRNAEYNP KRFGALIIRI TNPKTTALVF HSGKLVVTGG KTVDDSRLAG RKYARILQRL
     GYNVKFNHFK IQNVVASCDM KFAISLKELI QLAPKITKYE PEIFPGVVYR LADPKMVLLI
     FASGKIVFTG GKEIEQINKA FSEIYKILLQ VANNDN