ID   TBPL1_HUMAN             Reviewed;         186 AA.
AC   P62380; A8K8F5; O95753; Q9BWD5; Q9Z2Z0;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 158.
DE   RecName: Full=TATA box-binding protein-like 1;
DE            Short=TBP-like 1;
DE   AltName: Full=21 kDa TBP-like protein;
DE   AltName: Full=Second TBP of unique DNA protein;
DE            Short=STUD;
DE   AltName: Full=TATA box-binding protein-related factor 2;
DE            Short=TBP-related factor 2;
DE   AltName: Full=TBP-like factor;
DE   AltName: Full=TBP-related protein;
GN   Name=TBPL1; Synonyms=TLF, TLP, TLP21, TRF2, TRP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Retina;
RX   PubMed=10082669; DOI=10.1006/bbrc.1999.0159;
RA   Ohbayashi T., Kishimoto T., Makino Y., Shimada M., Nakadi T., Aoki T.,
RA   Kawata T., Niwa S., Tamura T.-A.;
RT   "Isolation of cDNA, chromosome mapping, and expression of the human TBP-
RT   like protein.";
RL   Biochem. Biophys. Res. Commun. 255:137-142(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH TFIIA AND TFIIB.
RX   PubMed=10220372; DOI=10.1073/pnas.96.9.4791;
RA   Rabenstein M.D., Zhou S., Lis J.T., Tjian R.;
RT   "TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of
RT   the TBP family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:4791-4796(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=15767669; DOI=10.1128/mcb.25.7.2632-2643.2005;
RA   Chong J.A., Moran M.M., Teichmann M., Kaczmarek J.S., Roeder R.,
RA   Clapham D.E.;
RT   "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of
RT   transcription: reciprocal regulation of the neurofibromatosis type 1 and c-
RT   fos genes by TLF/TRF2 and TBP.";
RL   Mol. Cell. Biol. 25:2632-2643(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis, and Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   TISSUE SPECIFICITY.
RX   PubMed=17570761; DOI=10.1089/dna.2006.0527;
RA   Di Pietro C., Ragusa M., Duro L., Guglielmino M.R., Barbagallo D.,
RA   Carnemolla A., Lagana A., Buffa P., Angelica R., Rinaldi A., Calafato M.S.,
RA   Milicia I., Caserta C., Giugno R., Pulvirenti A., Giunta V., Rapisarda A.,
RA   Di Pietro V., Grillo A., Messina A., Ferro A., Grzeschik K.H., Purrello M.;
RT   "Genomics, evolution, and expression of TBPL2, a member of the TBP
RT   family.";
RL   DNA Cell Biol. 26:369-385(2007).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [10]
RP   FUNCTION.
RX   PubMed=24958592; DOI=10.1101/gad.245662.114;
RA   Wang Y.L., Duttke S.H., Chen K., Johnston J., Kassavetis G.A.,
RA   Zeitlinger J., Kadonaga J.T.;
RT   "TRF2, but not TBP, mediates the transcription of ribosomal protein
RT   genes.";
RL   Genes Dev. 28:1550-1555(2014).
CC   -!- FUNCTION: Part of a specialized transcription system that mediates the
CC       transcription of most ribosomal proteins through the 5'-TCT-3' motif
CC       which is a core promoter element at these genes. Seems to also mediate
CC       the transcription of NF1. Does not bind the TATA box.
CC       {ECO:0000269|PubMed:10082669, ECO:0000269|PubMed:10220372,
CC       ECO:0000269|PubMed:15767669, ECO:0000269|PubMed:24958592}.
CC   -!- SUBUNIT: Binds TFIIA and TFIIB.
CC   -!- INTERACTION:
CC       P62380; Q92997: DVL3; NbExp=3; IntAct=EBI-716225, EBI-739789;
CC       P62380; P28799: GRN; NbExp=3; IntAct=EBI-716225, EBI-747754;
CC       P62380; P52655: GTF2A1; NbExp=5; IntAct=EBI-716225, EBI-389518;
CC       P62380; Q9Y4Y9: LSM5; NbExp=3; IntAct=EBI-716225, EBI-373007;
CC       P62380; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-716225, EBI-396669;
CC       P62380; P13805: TNNT1; NbExp=3; IntAct=EBI-716225, EBI-726527;
CC       P62380; O76024: WFS1; NbExp=3; IntAct=EBI-716225, EBI-720609;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in the
CC       testis and ovary. {ECO:0000269|PubMed:10082669,
CC       ECO:0000269|PubMed:17570761}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; AB020881; BAA75218.1; -; mRNA.
DR   EMBL; AF136570; AAD28785.1; -; mRNA.
DR   EMBL; AF130312; AAD24800.1; -; mRNA.
DR   EMBL; AK292320; BAF85009.1; -; mRNA.
DR   EMBL; AK313645; BAG36402.1; -; mRNA.
DR   EMBL; AL035699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW47995.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW47996.1; -; Genomic_DNA.
DR   EMBL; BC000381; AAH00381.1; -; mRNA.
DR   EMBL; BC017559; AAH17559.1; -; mRNA.
DR   CCDS; CCDS5168.1; -.
DR   PIR; JG0162; JG0162.
DR   RefSeq; NP_001240605.1; NM_001253676.1.
DR   RefSeq; NP_004856.1; NM_004865.3.
DR   RefSeq; XP_016867002.1; XM_017011513.1.
DR   AlphaFoldDB; P62380; -.
DR   SMR; P62380; -.
DR   BioGRID; 114896; 35.
DR   CORUM; P62380; -.
DR   IntAct; P62380; 17.
DR   MINT; P62380; -.
DR   STRING; 9606.ENSP00000237264; -.
DR   iPTMnet; P62380; -.
DR   PhosphoSitePlus; P62380; -.
DR   BioMuta; TBPL1; -.
DR   DMDM; 61248509; -.
DR   EPD; P62380; -.
DR   jPOST; P62380; -.
DR   MassIVE; P62380; -.
DR   MaxQB; P62380; -.
DR   PaxDb; P62380; -.
DR   PeptideAtlas; P62380; -.
DR   PRIDE; P62380; -.
DR   ProteomicsDB; 57399; -.
DR   Antibodypedia; 19728; 183 antibodies from 31 providers.
DR   DNASU; 9519; -.
DR   Ensembl; ENST00000237264.9; ENSP00000237264.3; ENSG00000028839.10.
DR   Ensembl; ENST00000613034.4; ENSP00000478795.1; ENSG00000028839.10.
DR   GeneID; 9519; -.
DR   KEGG; hsa:9519; -.
DR   MANE-Select; ENST00000237264.9; ENSP00000237264.3; NM_004865.4; NP_004856.1.
DR   UCSC; uc003qel.4; human.
DR   CTD; 9519; -.
DR   DisGeNET; 9519; -.
DR   GeneCards; TBPL1; -.
DR   HGNC; HGNC:11589; TBPL1.
DR   HPA; ENSG00000028839; Tissue enhanced (testis).
DR   MIM; 605521; gene.
DR   neXtProt; NX_P62380; -.
DR   OpenTargets; ENSG00000028839; -.
DR   PharmGKB; PA36353; -.
DR   VEuPathDB; HostDB:ENSG00000028839; -.
DR   eggNOG; KOG3302; Eukaryota.
DR   GeneTree; ENSGT00940000155712; -.
DR   InParanoid; P62380; -.
DR   OMA; NCEYEPE; -.
DR   OrthoDB; 1219067at2759; -.
DR   PhylomeDB; P62380; -.
DR   TreeFam; TF300102; -.
DR   PathwayCommons; P62380; -.
DR   SignaLink; P62380; -.
DR   BioGRID-ORCS; 9519; 20 hits in 1048 CRISPR screens.
DR   ChiTaRS; TBPL1; human.
DR   GeneWiki; TBPL1; -.
DR   GenomeRNAi; 9519; -.
DR   Pharos; P62380; Tbio.
DR   PRO; PR:P62380; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; P62380; protein.
DR   Bgee; ENSG00000028839; Expressed in oocyte and 200 other tissues.
DR   ExpressionAtlas; P62380; baseline and differential.
DR   Genevisible; P62380; HS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR   GO; GO:0005672; C:transcription factor TFIIA complex; IEA:Ensembl.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IDA:GO_Central.
DR   GO; GO:0001675; P:acrosome assembly; IEA:Ensembl.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:Ensembl.
DR   GO; GO:0007289; P:spermatid nucleus differentiation; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; TAS:UniProtKB.
DR   CDD; cd04517; TLF; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR015445; TBP-like.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..186
FT                   /note="TATA box-binding protein-like 1"
FT                   /id="PRO_0000153992"
FT   CONFLICT        44
FT                   /note="V -> A (in Ref. 7; AAH00381)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   186 AA;  20887 MW;  2CDD9F5E7BDDE63F CRC64;
     MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK LRKPRITATI
     WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF KVVNVLAVCN MPFEIRLPEF
     TKNNRPHASY EPELHPAVCY RIKSLRATLQ IFSTGSITVT GPNVKAVATA VEQIYPFVFE
     SRKEIL