TBPL1_MACFA
ID TBPL1_MACFA Reviewed; 186 AA.
AC Q4R848;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=TATA box-binding protein-like 1;
DE Short=TBP-like 1;
DE AltName: Full=TATA box-binding protein-related factor 2;
DE Short=TBP-related factor 2;
DE AltName: Full=TBP-like factor;
DE AltName: Full=TBP-related protein;
GN Name=TBPL1; Synonyms=TLF, TLP, TRF2, TRP; ORFNames=QtsA-13476;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of a specialized transcription system that mediates the
CC transcription of most ribosomal proteins through the 5'-TCT-3' motif
CC which is a core promoter element at these genes. Seems to also mediate
CC the transcription of NF1. Does not bind the TATA box (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Binds TFIIA and TFIIB. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR EMBL; AB168611; BAE00724.1; -; mRNA.
DR RefSeq; NP_001270159.1; NM_001283230.1.
DR RefSeq; XP_005551947.1; XM_005551890.2.
DR AlphaFoldDB; Q4R848; -.
DR SMR; Q4R848; -.
DR STRING; 9541.XP_005551946.1; -.
DR Ensembl; ENSMFAT00000017081; ENSMFAP00000042797; ENSMFAG00000040137.
DR GeneID; 101925911; -.
DR KEGG; mcf:101925911; -.
DR CTD; 9519; -.
DR VEuPathDB; HostDB:ENSMFAG00000040137; -.
DR eggNOG; KOG3302; Eukaryota.
DR GeneTree; ENSGT00940000155712; -.
DR OMA; NCEYEPE; -.
DR OrthoDB; 1219067at2759; -.
DR Proteomes; UP000233100; Chromosome 4.
DR Bgee; ENSMFAG00000040137; Expressed in lung and 13 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0005672; C:transcription factor TFIIA complex; IEA:Ensembl.
DR GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:Ensembl.
DR GO; GO:0001675; P:acrosome assembly; IEA:Ensembl.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:Ensembl.
DR GO; GO:0007289; P:spermatid nucleus differentiation; IEA:Ensembl.
DR CDD; cd04517; TLF; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR015445; TBP-like.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..186
FT /note="TATA box-binding protein-like 1"
FT /id="PRO_0000268202"
SQ SEQUENCE 186 AA; 20887 MW; 2CDD9F5E7BDDE63F CRC64;
MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK LRKPRITATI
WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF KVVNVLAVCN MPFEIRLPEF
TKNNRPHASY EPELHPAVCY RIKSLRATLQ IFSTGSITVT GPNVKAVATA VEQIYPFVFE
SRKEIL
