TBPL1_MOUSE
ID TBPL1_MOUSE Reviewed; 186 AA.
AC P62340; O95753; Q9Z2Z0;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=TATA box-binding protein-like 1;
DE Short=TBP-like 1;
DE AltName: Full=21 kDa TBP-like protein;
DE AltName: Full=TATA box-binding protein-related factor 2;
DE Short=TBP-related factor 2;
DE AltName: Full=TBP-like factor;
DE AltName: Full=TBP-related protein;
GN Name=Tbpl1; Synonyms=Tlf, Tlp, Tlp21, Trf2, Trp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=9889269; DOI=10.1093/nar/27.3.750;
RA Ohbayashi T., Makino Y., Tamura T.;
RT "Identification of a mouse TBP-like protein (TLP) distantly related to the
RT Drosophila TBP-related factor.";
RL Nucleic Acids Res. 27:750-755(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15767669; DOI=10.1128/mcb.25.7.2632-2643.2005;
RA Chong J.A., Moran M.M., Teichmann M., Kaczmarek J.S., Roeder R.,
RA Clapham D.E.;
RT "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of
RT transcription: reciprocal regulation of the neurofibromatosis type 1 and c-
RT fos genes by TLF/TRF2 and TBP.";
RL Mol. Cell. Biol. 25:2632-2643(2005).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=16412700; DOI=10.1016/j.modgep.2005.09.005;
RA Xiao L., Kim M., DeJong J.;
RT "Developmental and cell type-specific regulation of core promoter
RT transcription factors in germ cells of frogs and mice.";
RL Gene Expr. Patterns 6:409-419(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Part of a specialized transcription system that mediates the
CC transcription of most ribosomal proteins through the 5'-TCT-3' motif
CC which is a core promoter element at these genes (By similarity). Seems
CC to also mediate the transcription of NF1. Does not bind the TATA box.
CC {ECO:0000250, ECO:0000269|PubMed:15767669, ECO:0000269|PubMed:9889269}.
CC -!- SUBUNIT: Binds TFIIA and TFIIB. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:16412700, ECO:0000269|PubMed:9889269}.
CC -!- DISRUPTION PHENOTYPE: Significantly reduced NF1 levels.
CC {ECO:0000269|PubMed:15767669}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR EMBL; AB017697; BAA74578.1; -; mRNA.
DR EMBL; AK049975; BAC34014.1; -; mRNA.
DR EMBL; AK078547; BAC37330.1; -; mRNA.
DR CCDS; CCDS23730.1; -.
DR RefSeq; NP_035733.1; NM_011603.5.
DR RefSeq; XP_006512793.1; XM_006512730.3.
DR AlphaFoldDB; P62340; -.
DR SMR; P62340; -.
DR BioGRID; 231864; 6.
DR IntAct; P62340; 2.
DR MINT; P62340; -.
DR STRING; 10090.ENSMUSP00000114223; -.
DR PhosphoSitePlus; P62340; -.
DR EPD; P62340; -.
DR MaxQB; P62340; -.
DR PaxDb; P62340; -.
DR PeptideAtlas; P62340; -.
DR PRIDE; P62340; -.
DR ProteomicsDB; 262953; -.
DR Antibodypedia; 19728; 183 antibodies from 31 providers.
DR DNASU; 237336; -.
DR Ensembl; ENSMUST00000095794; ENSMUSP00000093470; ENSMUSG00000071359.
DR Ensembl; ENSMUST00000127698; ENSMUSP00000114223; ENSMUSG00000071359.
DR GeneID; 237336; -.
DR KEGG; mmu:237336; -.
DR UCSC; uc007epp.2; mouse.
DR CTD; 9519; -.
DR MGI; MGI:1339946; Tbpl1.
DR VEuPathDB; HostDB:ENSMUSG00000071359; -.
DR eggNOG; KOG3302; Eukaryota.
DR GeneTree; ENSGT00940000155712; -.
DR HOGENOM; CLU_060161_4_1_1; -.
DR InParanoid; P62340; -.
DR OMA; NCEYEPE; -.
DR OrthoDB; 1219067at2759; -.
DR PhylomeDB; P62340; -.
DR TreeFam; TF300102; -.
DR BioGRID-ORCS; 237336; 8 hits in 76 CRISPR screens.
DR ChiTaRS; Tbpl1; mouse.
DR PRO; PR:P62340; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; P62340; protein.
DR Bgee; ENSMUSG00000071359; Expressed in spermatid and 269 other tissues.
DR Genevisible; P62340; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0001673; C:male germ cell nucleus; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005672; C:transcription factor TFIIA complex; IDA:MGI.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; ISO:MGI.
DR GO; GO:0001675; P:acrosome assembly; IMP:MGI.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR GO; GO:0006235; P:dTTP biosynthetic process; IMP:MGI.
DR GO; GO:0007289; P:spermatid nucleus differentiation; IMP:MGI.
DR GO; GO:0007283; P:spermatogenesis; IDA:MGI.
DR CDD; cd04517; TLF; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR015445; TBP-like.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..186
FT /note="TATA box-binding protein-like 1"
FT /id="PRO_0000153993"
SQ SEQUENCE 186 AA; 20887 MW; 2CDD9F5E7BDDE63F CRC64;
MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK LRKPRITATI
WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF KVVNVLAVCN MPFEIRLPEF
TKNNRPHASY EPELHPAVCY RIKSLRATLQ IFSTGSITVT GPNVKAVATA VEQIYPFVFE
SRKEIL
