ID   TBPL1_PONAB             Reviewed;         190 AA.
AC   Q5R7U8;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=TATA box-binding protein-like 1;
DE            Short=TBP-like 1;
DE   AltName: Full=TATA box-binding protein-related factor 2;
DE            Short=TBP-related factor 2;
DE   AltName: Full=TBP-like factor;
DE   AltName: Full=TBP-related protein;
GN   Name=TBPL1; Synonyms=TLF, TLP, TRF2, TRP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of a specialized transcription system that mediates the
CC       transcription of most ribosomal proteins through the 5'-TCT-3' motif
CC       which is a core promoter element at these genes. Seems to also mediate
CC       the transcription of NF1. Does not bind the TATA box (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds TFIIA and TFIIB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; CR860011; CAH92162.1; -; mRNA.
DR   RefSeq; NP_001126267.1; NM_001132795.1.
DR   AlphaFoldDB; Q5R7U8; -.
DR   SMR; Q5R7U8; -.
DR   STRING; 9601.ENSPPYP00000019061; -.
DR   Ensembl; ENSPPYT00000019812; ENSPPYP00000019061; ENSPPYG00000017023.
DR   GeneID; 100173239; -.
DR   KEGG; pon:100173239; -.
DR   CTD; 9519; -.
DR   eggNOG; KOG3302; Eukaryota.
DR   GeneTree; ENSGT00940000155712; -.
DR   InParanoid; Q5R7U8; -.
DR   OrthoDB; 1219067at2759; -.
DR   Proteomes; UP000001595; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR   GO; GO:0005672; C:transcription factor TFIIA complex; IEA:Ensembl.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:Ensembl.
DR   GO; GO:0001675; P:acrosome assembly; IEA:Ensembl.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:Ensembl.
DR   GO; GO:0007289; P:spermatid nucleus differentiation; IEA:Ensembl.
DR   CDD; cd04517; TLF; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR015445; TBP-like.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..190
FT                   /note="TATA box-binding protein-like 1"
FT                   /id="PRO_0000293549"
SQ   SEQUENCE   190 AA;  21323 MW;  3F44DE516CDD9F5E CRC64;
     MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK LRKPRITATI
     WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF KVVNVLAVCN MPFEIRLPEF
     TKNNRPHASY EPELHPAVCY RIKSLRATLQ IFSTGSITVT GPNVKAVATA VEQIYPFVFE
     SRKEILSFTT