ID   TBPL1_XENLA             Reviewed;         186 AA.
AC   Q9W6Z2; Q5EAV8;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=TATA box-binding protein-like 1;
DE            Short=TBP-like 1;
DE   AltName: Full=TATA box-binding protein-related factor 2;
DE            Short=TBP-related factor 2;
DE   AltName: Full=TBP-like factor;
DE            Short=xlTLF;
GN   Name=tbpl1; Synonyms=tlf, trf2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neurula;
RX   PubMed=10470030; DOI=10.1016/s0968-0004(99)01436-x;
RA   Dantonel J.-C., Wurtz J.-M., Poch O., Moras D., Tora L.;
RT   "The TBP-like factor: an alternative transcription factor in metazoa?";
RL   Trends Biochem. Sci. 24:335-339(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=16412700; DOI=10.1016/j.modgep.2005.09.005;
RA   Xiao L., Kim M., DeJong J.;
RT   "Developmental and cell type-specific regulation of core promoter
RT   transcription factors in germ cells of frogs and mice.";
RL   Gene Expr. Patterns 6:409-419(2006).
RN   [4]
RP   FUNCTION.
RX   PubMed=17703192; DOI=10.1038/sj.emboj.7601822;
RA   Jacobi U.G., Akkers R.C., Pierson E.S., Weeks D.L., Dagle J.M.,
RA   Veenstra G.J.C.;
RT   "TBP paralogs accommodate metazoan- and vertebrate-specific developmental
RT   gene regulation.";
RL   EMBO J. 26:3900-3909(2007).
CC   -!- FUNCTION: Part of a specialized transcription system that mediates the
CC       transcription of most ribosomal proteins through the 5'-TCT-3' motif
CC       which is a core promoter element at these genes. Seems to also mediate
CC       the transcription of NF1. Does not bind the TATA box (By similarity).
CC       Members of the TBP family are differentially required to regulate
CC       transcription and development during early embryogenesis. Particularly
CC       regulates genes that have a role in catabolism. {ECO:0000250,
CC       ECO:0000269|PubMed:17703192}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously with highest expression in
CC       the ovary and testis. {ECO:0000269|PubMed:16412700}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ238441; CAB41487.1; -; mRNA.
DR   EMBL; BC090226; AAH90226.1; -; mRNA.
DR   RefSeq; NP_001083732.1; NM_001090263.1.
DR   AlphaFoldDB; Q9W6Z2; -.
DR   SMR; Q9W6Z2; -.
DR   MaxQB; Q9W6Z2; -.
DR   DNASU; 399086; -.
DR   GeneID; 399086; -.
DR   KEGG; xla:399086; -.
DR   CTD; 399086; -.
DR   Xenbase; XB-GENE-865785; tbpl1.L.
DR   OMA; NCEYEPE; -.
DR   OrthoDB; 1219067at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 399086; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:UniProtKB.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IMP:UniProtKB.
DR   CDD; cd04517; TLF; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR015445; TBP-like.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..186
FT                   /note="TATA box-binding protein-like 1"
FT                   /id="PRO_0000153995"
SQ   SEQUENCE   186 AA;  20961 MW;  FCFE24702F6F7F74 CRC64;
     MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGLNVIY KREVSKVLMK LRKPRITATI
     WSSGKIICTG ATSEEEAKVG ARRLARSLQK LGFQVKFTEF KVVNVLAVCT MPFEIRLNEF
     TKQNRPHASY EPELHPAVCY RIKSLRATLQ IFSTGSITVT GPDVKSVASA IEQIYPFVFE
     SRKTIL