ID   TBPL1_XENTR             Reviewed;         186 AA.
AC   Q6DIY4;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=TATA box-binding protein-like 1;
DE            Short=TBP-like 1;
DE   AltName: Full=TATA box-binding protein-related factor 2;
DE            Short=TBP-related factor 2;
DE   AltName: Full=TBP-like factor;
GN   Name=tbpl1; Synonyms=tlf, trf2; ORFNames=TEgg016a11.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION AS TBPL1.
RX   PubMed=17570761; DOI=10.1089/dna.2006.0527;
RA   Di Pietro C., Ragusa M., Duro L., Guglielmino M.R., Barbagallo D.,
RA   Carnemolla A., Lagana A., Buffa P., Angelica R., Rinaldi A., Calafato M.S.,
RA   Milicia I., Caserta C., Giugno R., Pulvirenti A., Giunta V., Rapisarda A.,
RA   Di Pietro V., Grillo A., Messina A., Ferro A., Grzeschik K.H., Purrello M.;
RT   "Genomics, evolution, and expression of TBPL2, a member of the TBP
RT   family.";
RL   DNA Cell Biol. 26:369-385(2007).
CC   -!- FUNCTION: Part of a specialized transcription system that mediates the
CC       transcription of most ribosomal proteins through the 5'-TCT-3' motif
CC       which is a core promoter element at these genes. Seems to also mediate
CC       the transcription of NF1. Does not bind the TATA box. Members of the
CC       TBP family are differentially required to regulate transcription and
CC       development during early embryogenesis. Particularly regulates genes
CC       that have a role in catabolism (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; CR760634; CAJ81743.1; -; mRNA.
DR   EMBL; BC075401; AAH75401.1; -; mRNA.
DR   RefSeq; NP_001004932.1; NM_001004932.1.
DR   AlphaFoldDB; Q6DIY4; -.
DR   SMR; Q6DIY4; -.
DR   PaxDb; Q6DIY4; -.
DR   Ensembl; ENSXETT00000000222; ENSXETP00000000222; ENSXETG00000000116.
DR   GeneID; 448323; -.
DR   KEGG; xtr:448323; -.
DR   CTD; 9519; -.
DR   Xenbase; XB-GENE-488460; tbpl1.
DR   eggNOG; KOG3302; Eukaryota.
DR   HOGENOM; CLU_060161_4_1_1; -.
DR   InParanoid; Q6DIY4; -.
DR   OMA; ITGCEVR; -.
DR   OrthoDB; 1219067at2759; -.
DR   PhylomeDB; Q6DIY4; -.
DR   TreeFam; TF300102; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000000116; Expressed in egg cell and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; ISS:UniProtKB.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd04517; TLF; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR015445; TBP-like.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..186
FT                   /note="TATA box-binding protein-like 1"
FT                   /id="PRO_0000293550"
SQ   SEQUENCE   186 AA;  20902 MW;  DCCD2A974AE0C5A5 CRC64;
     MDADSDVALD IIITNVVCVF RTRCHLNLRK IALEGLNVIY KREVGKVLMK LRKPRITATI
     WSSGKIICTG ATSEEEAKVG ARRLARSLQK LGFQVKFTEF KVVNVLAVCT MPFEIRLAEF
     TKQNRPHASY EPELHPAVCY RIKSLRTTLQ IFSTGSITVT GPDVKSVATA IEQIYPFVFE
     SRKAIL