TBPL2_DANRE
ID TBPL2_DANRE Reviewed; 312 AA.
AC Q1JPY4; Q6X484;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=TATA box-binding protein-like 2 {ECO:0000250|UniProtKB:Q6SJ94};
DE Short=TBP-like 2 {ECO:0000250|UniProtKB:Q6SJ94};
DE AltName: Full=TATA box-binding protein-related factor 3 {ECO:0000303|PubMed:18046332};
DE Short=TBP-related factor 3 {ECO:0000303|PubMed:18046332};
GN Name=tbpl2 {ECO:0000312|ZFIN:ZDB-GENE-040520-3};
GN Synonyms=tbp2, trf3 {ECO:0000303|PubMed:18046332};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAP87373.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=AB {ECO:0000312|EMBL:AAP87373.1};
RC TISSUE=Gonad {ECO:0000269|PubMed:15062100};
RX PubMed=15062100; DOI=10.1016/j.cub.2004.03.034;
RA Bartfai R., Balduf C., Hilton T., Rathmann Y., Hadzhiev Y., Tora L.,
RA Orban L., Mueller F.;
RT "TBP2, a vertebrate-specific member of the TBP family, is required in
RT embryonic development of zebrafish.";
RL Curr. Biol. 14:593-598(2004).
RN [2] {ECO:0000312|EMBL:AAI16554.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary {ECO:0000312|EMBL:AAI16554.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP FUNCTION.
RX PubMed=18046332; DOI=10.1038/nature06349;
RA Hart D.O., Raha T., Lawson N.D., Green M.R.;
RT "Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-
RT related factor Trf3.";
RL Nature 450:1082-1085(2007).
CC -!- FUNCTION: TATA box-binding transcription factor (By similarity).
CC Members of the TBP family are differentially required to regulate
CC transcription and development during early embryogenesis. Commits
CC mesoderm to the hematopoietic lineage during hemopoiesis, acting via
CC mespa. Binds to the mespa promoter. {ECO:0000250|UniProtKB:Q5UE94,
CC ECO:0000269|PubMed:15062100, ECO:0000269|PubMed:18046332}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5UE94}.
CC -!- TISSUE SPECIFICITY: In adults, expressed in the gonads, with expression
CC much higher in the ovary than the testis (at protein level). Shows a
CC small amount of expression in other adult organs, including the brain
CC and kidney. Embryonic expression is mostly ubiquitous except in early
CC gastrula embryos where expression is asymmetric.
CC {ECO:0000269|PubMed:15062100}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Already
CC present in fertilized eggs. Expression levels increase until the sphere
CC stage and reduce gradually toward 24 hpf (at protein level).
CC {ECO:0000269|PubMed:15062100}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255}.
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DR EMBL; AY256970; AAP87373.1; -; mRNA.
DR EMBL; BC116553; AAI16554.1; -; mRNA.
DR RefSeq; NP_999961.1; NM_214796.1.
DR AlphaFoldDB; Q1JPY4; -.
DR SMR; Q1JPY4; -.
DR STRING; 7955.ENSDARP00000051526; -.
DR PaxDb; Q1JPY4; -.
DR Ensembl; ENSDART00000051527; ENSDARP00000051526; ENSDARG00000097302.
DR GeneID; 407713; -.
DR KEGG; dre:407713; -.
DR CTD; 387332; -.
DR ZFIN; ZDB-GENE-040520-3; tbpl2.
DR eggNOG; KOG3302; Eukaryota.
DR GeneTree; ENSGT00940000159561; -.
DR HOGENOM; CLU_060161_1_2_1; -.
DR InParanoid; Q1JPY4; -.
DR OMA; GVDHNSQ; -.
DR OrthoDB; 1219067at2759; -.
DR PhylomeDB; Q1JPY4; -.
DR PRO; PR:Q1JPY4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 17.
DR Bgee; ENSDARG00000097302; Expressed in mature ovarian follicle and 15 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IDA:ZFIN.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:UniProtKB.
DR GO; GO:0009880; P:embryonic pattern specification; IMP:UniProtKB.
DR GO; GO:0030097; P:hemopoiesis; IMP:UniProtKB.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..312
FT /note="TATA box-binding protein-like 2"
FT /id="PRO_0000349148"
FT REGION 65..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 312 AA; 34738 MW; F5E6527EAFEB036F CRC64;
MNMDEEASLE SYFDQTIAGS SDYIFEGDLG LQGSTSQLQD SSFLSSLASQ EKDLTEDLDL
SFLPDELSTQ DEPSQVEKES KNEDSGIYTD CPQKESTQAD IDTSNSAQNT SQFNLPMTPM
TPMTPMTPVA ESSGIIPQLQ NIVSTVNLAC PLDLKSIALQ ARNAEYNPKR FAAVIMRIRE
PRTTALIFSS GKMVCTGAKS EEQSRLAARK YARVVQKLGF PAKFLDFKIQ NMVGSCDVCF
PIRLEGLVLT HQQFSSYEPE LFPGLIYRMV KPRIVLLIFV SGKVVLTGAK ERSEIYEAFE
NIYPILKGFR KQ
