TBPL2_HUMAN
ID TBPL2_HUMAN Reviewed; 375 AA.
AC Q6SJ96; Q17RU8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=TATA box-binding protein-like 2;
DE Short=TBP-like 2;
DE AltName: Full=TATA box-binding protein-related factor 3;
DE Short=TBP-related factor 3;
GN Name=TBPL2 {ECO:0000312|EMBL:AAI17186.1, ECO:0000312|HGNC:HGNC:19841};
GN Synonyms=TBP2, TRF3 {ECO:0000312|EMBL:AAR24281.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAR24281.1}
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=14634207; DOI=10.1073/pnas.2036440100;
RA Persengiev S.P., Zhu X., Dixit B.L., Maston G.A., Kittler E.L.W.,
RA Green M.R.;
RT "TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific
RT and widely expressed.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:14887-14891(2003).
RN [2] {ECO:0000305, ECO:0000312|EMBL:ABD93323.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=17570761; DOI=10.1089/dna.2006.0527;
RA Di Pietro C., Ragusa M., Duro L., Guglielmino M.R., Barbagallo D.,
RA Carnemolla A., Lagana A., Buffa P., Angelica R., Rinaldi A., Calafato M.S.,
RA Milicia I., Caserta C., Giugno R., Pulvirenti A., Giunta V., Rapisarda A.,
RA Di Pietro V., Grillo A., Messina A., Ferro A., Grzeschik K.H., Purrello M.;
RT "Genomics, evolution, and expression of TBPL2, a member of the TBP
RT family.";
RL DNA Cell Biol. 26:369-385(2007).
RN [3] {ECO:0000312|EMBL:AAI17160.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-31.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcription factor required in complex with TAF3 for the
CC differentiation of myoblasts into myocytes. The complex replaces TFIID
CC at specific promoters at an early stage in the differentiation process
CC (By similarity). {ECO:0000250|UniProtKB:Q6SJ95}.
CC -!- SUBUNIT: Interacts with TAF3. {ECO:0000250|UniProtKB:Q6SJ95}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14634207}. Nucleus
CC {ECO:0000269|PubMed:14634207}. Note=Present in the cytoplasm during
CC cytokinesis. {ECO:0000269|PubMed:14634207}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed in all tissues examined with
CC highest levels in heart, lung, ovary, spleen and testes.
CC {ECO:0000269|PubMed:14634207, ECO:0000269|PubMed:17570761}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255}.
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DR EMBL; AY457923; AAR24281.1; -; mRNA.
DR EMBL; DQ448593; ABD93323.1; -; mRNA.
DR EMBL; BC117159; AAI17160.1; -; mRNA.
DR EMBL; BC117185; AAI17186.1; -; mRNA.
DR RefSeq; NP_950248.1; NM_199047.2.
DR AlphaFoldDB; Q6SJ96; -.
DR SMR; Q6SJ96; -.
DR BioGRID; 132286; 10.
DR STRING; 9606.ENSP00000247219; -.
DR iPTMnet; Q6SJ96; -.
DR PhosphoSitePlus; Q6SJ96; -.
DR BioMuta; TBPL2; -.
DR DMDM; 74749326; -.
DR EPD; Q6SJ96; -.
DR jPOST; Q6SJ96; -.
DR MassIVE; Q6SJ96; -.
DR MaxQB; Q6SJ96; -.
DR PaxDb; Q6SJ96; -.
DR PeptideAtlas; Q6SJ96; -.
DR PRIDE; Q6SJ96; -.
DR ProteomicsDB; 67358; -.
DR Antibodypedia; 61077; 125 antibodies from 22 providers.
DR DNASU; 387332; -.
DR Ensembl; ENST00000247219.5; ENSP00000247219.5; ENSG00000182521.5.
DR GeneID; 387332; -.
DR KEGG; hsa:387332; -.
DR MANE-Select; ENST00000247219.6; ENSP00000247219.6; NM_199047.3; NP_950248.2.
DR UCSC; uc001xby.5; human.
DR CTD; 387332; -.
DR DisGeNET; 387332; -.
DR GeneCards; TBPL2; -.
DR HGNC; HGNC:19841; TBPL2.
DR HPA; ENSG00000182521; Tissue enhanced (skeletal).
DR MIM; 608964; gene.
DR neXtProt; NX_Q6SJ96; -.
DR OpenTargets; ENSG00000182521; -.
DR PharmGKB; PA134990291; -.
DR VEuPathDB; HostDB:ENSG00000182521; -.
DR eggNOG; KOG3302; Eukaryota.
DR GeneTree; ENSGT00940000159561; -.
DR HOGENOM; CLU_060161_1_2_1; -.
DR InParanoid; Q6SJ96; -.
DR OMA; MEQEETY; -.
DR OrthoDB; 1219067at2759; -.
DR PhylomeDB; Q6SJ96; -.
DR TreeFam; TF300102; -.
DR PathwayCommons; Q6SJ96; -.
DR SignaLink; Q6SJ96; -.
DR SIGNOR; Q6SJ96; -.
DR BioGRID-ORCS; 387332; 12 hits in 1067 CRISPR screens.
DR ChiTaRS; TBPL2; human.
DR GenomeRNAi; 387332; -.
DR Pharos; Q6SJ96; Tbio.
DR PRO; PR:Q6SJ96; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q6SJ96; protein.
DR Bgee; ENSG00000182521; Expressed in sural nerve and 39 other tissues.
DR ExpressionAtlas; Q6SJ96; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0001674; C:female germ cell nucleus; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..375
FT /note="TATA box-binding protein-like 2"
FT /id="PRO_0000318118"
FT REGION 103..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 31
FT /note="R -> P (in dbSNP:rs8019270)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_038692"
SQ SEQUENCE 375 AA; 41524 MW; E55539A49FE76704 CRC64;
MASAPWPERV PRLLAPRLPS YPPPPPTVGL RSMEQEETYL ELYLDQCAAQ DGLAPPRSPL
FSPVVPYDMY ILNASNPDTA FNSNPEVKET SGDFSSVDLS FLPDEVTQEN KDQPVISKHE
TEENSESQSP QSRLPSPSEQ DVGLGLNSSS LSNSHSQLHP GDTDSVQPSP EKPNSDSLSL
ASITPMTPMT PISECCGIVP QLQNIVSTVN LACKLDLKKI ALHAKNAEYN PKRFAAVIMR
IREPRTTALI FSSGKMVCTG AKSEEQSRLA ARKYARVVQK LGFPARFLDF KIQNMVGSCD
VRFPIRLEGL VLTHQQFSSY EPELFPGLIY RMVKPRIVLL IFVSGKVVLT GAKERSEIYE
AFENIYPILK GFKKA
