TBPL2_MOUSE
ID TBPL2_MOUSE Reviewed; 350 AA.
AC Q6SJ95; A2AQK6; Q498A1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=TATA box-binding protein-like 2;
DE Short=TBP-like 2;
DE AltName: Full=TATA box-binding protein-related factor 3;
DE Short=TBP-related factor 3;
GN Name=Tbpl2 {ECO:0000312|MGI:MGI:2684058};
GN Synonyms=Tbp2, Trf3 {ECO:0000312|EMBL:AAR24282.1,
GN ECO:0000312|MGI:MGI:2684058};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAR24282.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Swiss Webster {ECO:0000312|EMBL:AAR24282.1};
RX PubMed=14634207; DOI=10.1073/pnas.2036440100;
RA Persengiev S.P., Zhu X., Dixit B.L., Maston G.A., Kittler E.L.W.,
RA Green M.R.;
RT "TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific
RT and widely expressed.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:14887-14891(2003).
RN [2] {ECO:0000312|EMBL:DAA06033.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=17570761; DOI=10.1089/dna.2006.0527;
RA Di Pietro C., Ragusa M., Duro L., Guglielmino M.R., Barbagallo D.,
RA Carnemolla A., Lagana A., Buffa P., Angelica R., Rinaldi A., Calafato M.S.,
RA Milicia I., Caserta C., Giugno R., Pulvirenti A., Giunta V., Rapisarda A.,
RA Di Pietro V., Grillo A., Messina A., Ferro A., Grzeschik K.H., Purrello M.;
RT "Genomics, evolution, and expression of TBPL2, a member of the TBP
RT family.";
RL DNA Cell Biol. 26:369-385(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0000312|EMBL:AAI19161.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57B16/J; TISSUE=Oocyte;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=15062100; DOI=10.1016/j.cub.2004.03.034;
RA Bartfai R., Balduf C., Hilton T., Rathmann Y., Hadzhiev Y., Tora L.,
RA Orban L., Mueller F.;
RT "TBP2, a vertebrate-specific member of the TBP family, is required in
RT embryonic development of zebrafish.";
RL Curr. Biol. 14:593-598(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=16412700; DOI=10.1016/j.modgep.2005.09.005;
RA Xiao L., Kim M., DeJong J.;
RT "Developmental and cell type-specific regulation of core promoter
RT transcription factors in germ cells of frogs and mice.";
RL Gene Expr. Patterns 6:409-419(2006).
RN [7] {ECO:0000305}
RP FUNCTION, INTERACTION WITH TAF3, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=17704303; DOI=10.1101/gad.1583407;
RA Deato M.D.E., Tjian R.;
RT "Switching of the core transcription machinery during myogenesis.";
RL Genes Dev. 21:2137-2149(2007).
CC -!- FUNCTION: Transcription factor required in complex with TAF3 for the
CC differentiation of myoblasts into myocytes. The complex replaces TFIID
CC at specific promoters at an early stage in the differentiation process.
CC {ECO:0000269|PubMed:17704303}.
CC -!- SUBUNIT: Interacts with TAF3. {ECO:0000269|PubMed:17704303}.
CC -!- INTERACTION:
CC Q6SJ95; Q5HZG4: Taf3; NbExp=3; IntAct=EBI-1571412, EBI-1561080;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6SJ96,
CC ECO:0000269|PubMed:17704303}. Nucleus {ECO:0000250|UniProtKB:Q6SJ96,
CC ECO:0000269|PubMed:17704303}. Note=Present in the cytoplasm during
CC cytokinesis. {ECO:0000250|UniProtKB:Q6SJ96}.
CC -!- TISSUE SPECIFICITY: Expressed in myotubes and myofibers (at protein
CC level). Expressed in a wide variety of tissues with highest levels in
CC heart, lung, liver, uterus and placenta and especially the gonads.
CC Expression is higher in the ovary than the testis, and within the ovary
CC expression is localized to the oocytes. {ECO:0000269|PubMed:14634207,
CC ECO:0000269|PubMed:15062100, ECO:0000269|PubMed:16412700,
CC ECO:0000269|PubMed:17704303}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255}.
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DR EMBL; AY457924; AAR24282.1; -; mRNA.
DR EMBL; BK005773; DAA06033.1; -; mRNA.
DR EMBL; AL844838; CAM19020.1; -; Genomic_DNA.
DR EMBL; AL844838; CAM19021.1; -; Genomic_DNA.
DR EMBL; BC100305; AAI00306.1; -; mRNA.
DR EMBL; BC119160; AAI19161.1; -; mRNA.
DR CCDS; CCDS15732.1; -.
DR RefSeq; NP_001276618.1; NM_001289689.1.
DR RefSeq; NP_951014.1; NM_199059.2.
DR AlphaFoldDB; Q6SJ95; -.
DR SMR; Q6SJ95; -.
DR IntAct; Q6SJ95; 1.
DR STRING; 10090.ENSMUSP00000079309; -.
DR PhosphoSitePlus; Q6SJ95; -.
DR MaxQB; Q6SJ95; -.
DR PaxDb; Q6SJ95; -.
DR PRIDE; Q6SJ95; -.
DR ProteomicsDB; 254832; -.
DR Antibodypedia; 61077; 125 antibodies from 22 providers.
DR DNASU; 227606; -.
DR Ensembl; ENSMUST00000080453; ENSMUSP00000079309; ENSMUSG00000061809.
DR GeneID; 227606; -.
DR KEGG; mmu:227606; -.
DR UCSC; uc008iol.2; mouse.
DR CTD; 387332; -.
DR MGI; MGI:2684058; Tbpl2.
DR VEuPathDB; HostDB:ENSMUSG00000061809; -.
DR eggNOG; KOG3302; Eukaryota.
DR GeneTree; ENSGT00940000159561; -.
DR InParanoid; Q6SJ95; -.
DR OMA; MEQEETY; -.
DR OrthoDB; 1219067at2759; -.
DR PhylomeDB; Q6SJ95; -.
DR TreeFam; TF300102; -.
DR BioGRID-ORCS; 227606; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q6SJ95; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q6SJ95; protein.
DR Bgee; ENSMUSG00000061809; Expressed in morula and 6 other tissues.
DR ExpressionAtlas; Q6SJ95; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0001674; C:female germ cell nucleus; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..350
FT /note="TATA box-binding protein-like 2"
FT /id="PRO_0000318119"
FT REGION 82..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 294
FT /note="Missing (in Ref. 2; DAA06033, 3; CAM19021 and 4;
FT AAI00306)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 350 AA; 38967 MW; A436F5AE830B5CCB CRC64;
MVGSLIMEED IYLDLFLDPY TIQDDFPPAM SQLFSPGVPL DMHSLPSNPE TVFHPHLGGV
KKASTDFSSV DLSFLPDELT QENRDQTVTG NKLASEESCR TRDRQSQLQL PDEHGSELNL
NSNSSPDPQS CLCFDDAHSN QPSPETPNSN ALPVALIASM MPMNPVPGFS GIVPQLQNVV
STANLACKLD LRKIALNAKN TEYNPKRFAA VIMRIREPRT TALIFSSGKV VCTGAKSEEE
SRLAARKYAR VVQKLGFPVR FFNFKIQNMV GSCDVKFPIR LEILALTHRQ FSSSYEPELF
PGLIYKMVKP QVVLLIFASG KVVLTGAKER SEIYEAFENM YPILESFKKV
