ID   TBPL2_PANTR             Reviewed;         376 AA.
AC   A6H907;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=TATA box-binding protein-like 2;
DE            Short=TBP-like 2;
DE   AltName: Full=TATA box-binding protein-related factor 3;
DE            Short=TBP-related factor 3;
GN   Name=TBPL2 {ECO:0000250|UniProtKB:P62380};
GN   Synonyms=TBP2, TRF3 {ECO:0000250|UniProtKB:P62380};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:DAA06032.1}
RP   IDENTIFICATION.
RX   PubMed=17570761; DOI=10.1089/dna.2006.0527;
RA   Di Pietro C., Ragusa M., Duro L., Guglielmino M.R., Barbagallo D.,
RA   Carnemolla A., Lagana A., Buffa P., Angelica R., Rinaldi A., Calafato M.S.,
RA   Milicia I., Caserta C., Giugno R., Pulvirenti A., Giunta V., Rapisarda A.,
RA   Di Pietro V., Grillo A., Messina A., Ferro A., Grzeschik K.H., Purrello M.;
RT   "Genomics, evolution, and expression of TBPL2, a member of the TBP
RT   family.";
RL   DNA Cell Biol. 26:369-385(2007).
CC   -!- FUNCTION: Transcription factor required in complex with TAF3 for the
CC       differentiation of myoblasts into myocytes. The complex replaces TFIID
CC       at specific promoters at an early stage in the differentiation process
CC       (By similarity). {ECO:0000250|UniProtKB:Q6SJ95}.
CC   -!- SUBUNIT: Interacts with TAF3. {ECO:0000250|UniProtKB:Q6SJ95}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6SJ96}. Nucleus
CC       {ECO:0000250|UniProtKB:Q6SJ96}. Note=Present in the cytoplasm during
CC       cytokinesis. {ECO:0000250|UniProtKB:Q6SJ96}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255}.
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DR   EMBL; AADA01072659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AADA01300750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AADA01358262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK005772; DAA06032.1; -; mRNA.
DR   RefSeq; NP_001098076.1; NM_001104606.1.
DR   AlphaFoldDB; A6H907; -.
DR   SMR; A6H907; -.
DR   STRING; 9598.ENSPTRP00000010815; -.
DR   PaxDb; A6H907; -.
DR   GeneID; 452923; -.
DR   CTD; 387332; -.
DR   eggNOG; KOG3302; Eukaryota.
DR   InParanoid; A6H907; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   CDD; cd04516; TBP_eukaryotes; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   InterPro; IPR033710; TBP_eukaryotic.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..376
FT                   /note="TATA box-binding protein-like 2"
FT                   /id="PRO_0000318120"
FT   REGION          103..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..126
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   376 AA;  41507 MW;  E160738B7D76B3F8 CRC64;
     MASAPWPERV PRLLAPRLPS YPPPPPTVGL PSMEQEEAYL ELYLDQCAAQ DGLAPPRSPL
     FSPVVPYDMY ILNASNPDTA FNSNPEVKET SGDFSSVDLS FLPDEVTQEN KDQPVISKHE
     TEENSESQSP QSRLPSPSEQ DVGLGLNSSS LSNSHSQLHP GDTDSVQPSP EKPNSDSLSL
     ASITPMTPMT PISECCGIVP QLQNIVSTVN LACKLDLKKI ALHAKNAEYN PKRFAAVIMR
     IREPRTTALI FSSGKMVCTG AKSEEQSRLA ARKYARVVQK LGFPAKFLDF KIQNMVGSCD
     VKFPIRLEGL VLTHQQFSSY EPELFPGLIY RMIKPRIVLL IFVSGKVVLT GAKVRAEIYE
     AFENIYPILK GFRKTT