ID   TBPL2_RAT               Reviewed;         344 AA.
AC   A6H909;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=TATA box-binding protein-like 2;
DE            Short=TBP-like 2;
DE   AltName: Full=TATA box-binding protein-related factor 3;
DE            Short=TBP-related factor 3;
GN   Name=Tbpl2 {ECO:0000250|UniProtKB:P62380};
GN   Synonyms=Tbp2, Trf3 {ECO:0000250|UniProtKB:P62380};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:DAA06034.1}
RP   IDENTIFICATION.
RX   PubMed=17570761; DOI=10.1089/dna.2006.0527;
RA   Di Pietro C., Ragusa M., Duro L., Guglielmino M.R., Barbagallo D.,
RA   Carnemolla A., Lagana A., Buffa P., Angelica R., Rinaldi A., Calafato M.S.,
RA   Milicia I., Caserta C., Giugno R., Pulvirenti A., Giunta V., Rapisarda A.,
RA   Di Pietro V., Grillo A., Messina A., Ferro A., Grzeschik K.H., Purrello M.;
RT   "Genomics, evolution, and expression of TBPL2, a member of the TBP
RT   family.";
RL   DNA Cell Biol. 26:369-385(2007).
CC   -!- FUNCTION: Transcription factor required in complex with TAF3 for the
CC       differentiation of myoblasts into myocytes. The complex replaces TFIID
CC       at specific promoters at an early stage in the differentiation process
CC       (By similarity). {ECO:0000250|UniProtKB:Q6SJ95}.
CC   -!- SUBUNIT: Interacts with TAF3. {ECO:0000250|UniProtKB:Q6SJ95}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6SJ96}. Nucleus
CC       {ECO:0000250|UniProtKB:Q6SJ96}. Note=Present in the cytoplasm during
CC       cytokinesis. {ECO:0000250|UniProtKB:Q6SJ96}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255}.
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DR   EMBL; AAHX01020401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK005774; DAA06034.1; -; mRNA.
DR   RefSeq; NP_001092831.1; NM_001099361.1.
DR   AlphaFoldDB; A6H909; -.
DR   SMR; A6H909; -.
DR   STRING; 10116.ENSRNOP00000039739; -.
DR   PaxDb; A6H909; -.
DR   GeneID; 680050; -.
DR   KEGG; rno:680050; -.
DR   UCSC; RGD:1596837; rat.
DR   CTD; 387332; -.
DR   RGD; 1596837; Tbpl2.
DR   VEuPathDB; HostDB:ENSRNOG00000033682; -.
DR   eggNOG; KOG3302; Eukaryota.
DR   HOGENOM; CLU_060161_1_2_1; -.
DR   InParanoid; A6H909; -.
DR   OMA; MEQEETY; -.
DR   OrthoDB; 1219067at2759; -.
DR   PhylomeDB; A6H909; -.
DR   PRO; PR:A6H909; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000033682; Expressed in ovary.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0003677; F:DNA binding; ISO:RGD.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   CDD; cd04516; TBP_eukaryotes; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   InterPro; IPR033710; TBP_eukaryotic.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="TATA box-binding protein-like 2"
FT                   /id="PRO_0000318121"
FT   REGION          78..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..143
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   344 AA;  38355 MW;  CAA7FFAC7482F732 CRC64;
     MEEDMYVDIF LDPYTFQDDF PPATSQLFSP GAPLDVHPLN PSNPETVFHS HLGAVKKAPS
     DFSSVDLSFL PDELTQENKD RTVTGNKVTN EESFRTQDWQ SQLQLPDEQG SGLNLNSNSS
     PDTQSCLCSH DADSNQLSSE TPNSNALPVV LISSMTPMNP VTECSGIVPQ LQNVVSTANL
     ACKLDLRKIA LNAKNTEYNP KRFAAVIMRI REPRTTALIF SSGKVVCTGA KSEDESRLAA
     RKYARVVQKL GFPVRFFNFK IQNMVASCDV KFPIRLEILA LTHRQFSSYE PELFPGLIYK
     MVKPQVVLLI FASGKVVLTG AKERSEIYEA FENMYPILES FKKV