TBPL2_XENLA
ID TBPL2_XENLA Reviewed; 320 AA.
AC Q5UE94; Q6IM79;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=TATA box-binding protein-like 2 {ECO:0000250|UniProtKB:Q28DH2};
DE Short=TBP-like 2 {ECO:0000250|UniProtKB:Q28DH2};
DE AltName: Full=TATA box-binding protein-related factor 3 {ECO:0000303|PubMed:14634207};
DE Short=TBP-related factor 3 {ECO:0000303|PubMed:14634207};
GN Name=tbpl2 {ECO:0000250|UniProtKB:Q28DH2};
GN Synonyms=tbp2 {ECO:0000303|PubMed:15345743},
GN trf3 {ECO:0000312|EMBL:DAA02137.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAV34742.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=15345743; DOI=10.1073/pnas.0405536101;
RA Jallow Z., Jacobi U.G., Weeks D.L., Dawid I.B., Veenstra G.J.C.;
RT "Specialized and redundant roles of TBP and a vertebrate-specific TBP
RT paralog in embryonic gene regulation in Xenopus.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:13525-13530(2004).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-223.
RX PubMed=11311557; DOI=10.1016/s0378-1119(01)00383-3;
RA Blackshear P.J., Lai W.S., Thorn J.M., Kennington E.A., Staffa N.G. Jr.,
RA Moore D.T., Bouffard G.G., Beckstrom-Sternberg S.M., Touchman J.W.,
RA Bonaldo M.F., Soares M.B.;
RT "The NIEHS Xenopus maternal EST project: interim analysis of the first
RT 13,879 ESTs from unfertilized eggs.";
RL Gene 267:71-87(2001).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 135-320.
RA Clifton S., Johnson S.L., Blumberg B., Song J., Hillier L., Pape D.,
RA Martin J., Wylie T., Underwood K., Theising B., Bowers Y., Person B.,
RA Gibbons M., Harvey N., Ritter E., Jackson Y., McCann R., Waterston R.,
RA Wilson R.;
RT "WashU Xenopus EST project, 1999.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305, ECO:0000312|EMBL:DAA02137.1}
RP IDENTIFICATION.
RX PubMed=14634207; DOI=10.1073/pnas.2036440100;
RA Persengiev S.P., Zhu X., Dixit B.L., Maston G.A., Kittler E.L.W.,
RA Green M.R.;
RT "TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific
RT and widely expressed.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:14887-14891(2003).
RN [5] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=15062100; DOI=10.1016/j.cub.2004.03.034;
RA Bartfai R., Balduf C., Hilton T., Rathmann Y., Hadzhiev Y., Tora L.,
RA Orban L., Mueller F.;
RT "TBP2, a vertebrate-specific member of the TBP family, is required in
RT embryonic development of zebrafish.";
RL Curr. Biol. 14:593-598(2004).
RN [6] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=16412700; DOI=10.1016/j.modgep.2005.09.005;
RA Xiao L., Kim M., DeJong J.;
RT "Developmental and cell type-specific regulation of core promoter
RT transcription factors in germ cells of frogs and mice.";
RL Gene Expr. Patterns 6:409-419(2006).
RN [7] {ECO:0000305}
RP FUNCTION.
RX PubMed=17703192; DOI=10.1038/sj.emboj.7601822;
RA Jacobi U.G., Akkers R.C., Pierson E.S., Weeks D.L., Dagle J.M.,
RA Veenstra G.J.C.;
RT "TBP paralogs accommodate metazoan- and vertebrate-specific developmental
RT gene regulation.";
RL EMBO J. 26:3900-3909(2007).
CC -!- FUNCTION: TATA box-binding transcription factor. Members of the TBP
CC family are differentially required to regulate transcription and
CC development during early embryogenesis. Required for gastrulation.
CC Regulates a large subset of genes that are ventrally expressed. Binds
CC to a subset of promoters. {ECO:0000250|UniProtKB:Q28DH2,
CC ECO:0000269|PubMed:15345743, ECO:0000269|PubMed:17703192}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15345743}.
CC -!- TISSUE SPECIFICITY: Expression is restricted to the gonads, and is
CC higher in the ovary than the testis. {ECO:0000269|PubMed:15062100,
CC ECO:0000269|PubMed:16412700}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Abundant in oocytes and expressed in embryos at a lower level, dropping
CC between embryonic stages 6.5 and 12. {ECO:0000269|PubMed:15345743,
CC ECO:0000269|PubMed:16412700}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255}.
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DR EMBL; AY753184; AAV34742.1; -; mRNA.
DR EMBL; AW633235; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AW638001; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BI349806; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BI443085; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BK001774; DAA02137.1; -; mRNA.
DR RefSeq; NP_001080921.1; NM_001087452.2.
DR AlphaFoldDB; Q5UE94; -.
DR SMR; Q5UE94; -.
DR GeneID; 387333; -.
DR KEGG; xla:387333; -.
DR CTD; 387333; -.
DR Xenbase; XB-GENE-876147; tbpl2.L.
DR OMA; FTPSECR; -.
DR OrthoDB; 1219067at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 387333; Expressed in egg cell and 6 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:UniProtKB.
DR GO; GO:0007369; P:gastrulation; IMP:UniProtKB.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:0006351; P:transcription, DNA-templated; IDA:UniProtKB.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Gastrulation; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..320
FT /note="TATA box-binding protein-like 2"
FT /id="PRO_0000349150"
FT CONFLICT 145
FT /note="Q -> H (in Ref. 3; BI349806)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="I -> N (in Ref. 3; BI349806)"
FT /evidence="ECO:0000305"
FT CONFLICT 185
FT /note="I -> N (in Ref. 3; BI349806)"
FT /evidence="ECO:0000305"
FT CONFLICT 262
FT /note="S -> N (in Ref. 3; BI443085)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 320 AA; 35709 MW; 51ABCE141A41B5B3 CRC64;
MDGESSLERY LDQCDAEDVL ASSHMFTPMT PYDDLAIQPL PGTSYSSTLE HSKELSTDFS
SVDLSFLPDD LNQENEDQQE QTPSQSLEHD SGICLDASNL SQPFTPSECR DATQDSSNLC
TMPITPMTPM TPMTPVAESS GIVPQLQNIV STVNLACKLD LKKIALHARN AEYNPKRFAA
VIMRIREPRT TALIFSSGKM VCTGAKSEEQ SRLAARKYAR VVQKLGFPAK FLDFKIQNMV
GSCDVRFPIR LEGLVLTHQQ FSSYEPELFP GLIYRMVKPR IVLLIFVSGK VVLTGAKERS
EIYEAFENIY PILKGFKKTT
