ID   TBPL2_XENTR             Reviewed;         322 AA.
AC   Q28DH2;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=TATA box-binding protein-like 2 {ECO:0000303|PubMed:17570761};
DE            Short=TBP-like 2 {ECO:0000303|PubMed:17570761};
DE            Short=xTBPL2 {ECO:0000303|PubMed:17570761};
DE   AltName: Full=TATA box-binding protein-related factor 3 {ECO:0000250|UniProtKB:Q5UE94};
DE            Short=TBP-related factor 3 {ECO:0000250|UniProtKB:Q5UE94};
GN   Name=tbpl2 {ECO:0000303|PubMed:17570761};
GN   Synonyms=tbp2 {ECO:0000303|PubMed:17703192},
GN   trf3 {ECO:0000250|UniProtKB:Q5UE94}; ORFNames=TEgg129i22.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ81377.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg {ECO:0000312|EMBL:CAJ81377.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   IDENTIFICATION AS TBPL2.
RX   PubMed=17570761; DOI=10.1089/dna.2006.0527;
RA   Di Pietro C., Ragusa M., Duro L., Guglielmino M.R., Barbagallo D.,
RA   Carnemolla A., Lagana A., Buffa P., Angelica R., Rinaldi A., Calafato M.S.,
RA   Milicia I., Caserta C., Giugno R., Pulvirenti A., Giunta V., Rapisarda A.,
RA   Di Pietro V., Grillo A., Messina A., Ferro A., Grzeschik K.H., Purrello M.;
RT   "Genomics, evolution, and expression of TBPL2, a member of the TBP
RT   family.";
RL   DNA Cell Biol. 26:369-385(2007).
RN   [3] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=17703192; DOI=10.1038/sj.emboj.7601822;
RA   Jacobi U.G., Akkers R.C., Pierson E.S., Weeks D.L., Dagle J.M.,
RA   Veenstra G.J.C.;
RT   "TBP paralogs accommodate metazoan- and vertebrate-specific developmental
RT   gene regulation.";
RL   EMBO J. 26:3900-3909(2007).
CC   -!- FUNCTION: TATA box-binding transcription factor. Members of the TBP
CC       family are differentially required to regulate transcription and
CC       development during early embryogenesis. Required for gastrulation.
CC       Regulates a large subset of genes that are ventrally expressed (By
CC       similarity). Binds to a subset of promoters.
CC       {ECO:0000250|UniProtKB:Q5UE94, ECO:0000269|PubMed:17703192}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5UE94}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255}.
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DR   EMBL; CR855514; CAJ81377.1; -; mRNA.
DR   RefSeq; NP_001017309.1; NM_001017309.2.
DR   AlphaFoldDB; Q28DH2; -.
DR   SMR; Q28DH2; -.
DR   PaxDb; Q28DH2; -.
DR   Ensembl; ENSXETT00000034256; ENSXETP00000034256; ENSXETG00000015710.
DR   GeneID; 550063; -.
DR   KEGG; xtr:550063; -.
DR   CTD; 387332; -.
DR   Xenbase; XB-GENE-876138; tbpl2.
DR   eggNOG; KOG3302; Eukaryota.
DR   HOGENOM; CLU_060161_1_2_1; -.
DR   InParanoid; Q28DH2; -.
DR   OMA; FTPSECR; -.
DR   OrthoDB; 1219067at2759; -.
DR   PhylomeDB; Q28DH2; -.
DR   TreeFam; TF300102; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015710; Expressed in ovary and 6 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; ISS:UniProtKB.
DR   GO; GO:0009880; P:embryonic pattern specification; IEA:Ensembl.
DR   GO; GO:0007369; P:gastrulation; ISS:UniProtKB.
DR   GO; GO:0030097; P:hemopoiesis; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006351; P:transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd04516; TBP_eukaryotes; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   InterPro; IPR033710; TBP_eukaryotic.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Gastrulation; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..322
FT                   /note="TATA box-binding protein-like 2"
FT                   /id="PRO_0000349151"
SQ   SEQUENCE   322 AA;  35862 MW;  765B488EB025B1AF CRC64;
     MDGESSLERY LDQCDAEDVL ASSAHMYTPM TPYDDLAIQP LPGTSYSSAL EQSKELSTDF
     SSVDLSFLPD DLNQENEDQQ EQQTSSQSLE QDSGICLDAS NLSQPFTPSE CRDASQDSTN
     LCPMPITPMT PMTPMTPVAE SSGIVPQLQN IVSTVNLACK LDLKKIALHA RNAEYNPKRF
     AAVIMRIREP RTTALIFSSG KMVCTGAKSE EQSRLAARKY ARVVQKLGFP AKFLDFKIQN
     MVGSCDVRFP IRLEGLVLTH QQFSSYEPEL FPGLIYRMVK PRIVLLIFVS GKVVLTGAKE
     RSEIYEAFEN IYPILKGFKK TT