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TBP_ACACA
ID   TBP_ACACA               Reviewed;         258 AA.
AC   P26354;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=TATA-box-binding protein;
DE   AltName: Full=TATA sequence-binding protein;
DE            Short=TBP;
DE   AltName: Full=TATA-binding factor;
DE   AltName: Full=TATA-box factor;
DE   AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN   Name=TFIID;
OS   Acanthamoeba castellanii (Amoeba).
OC   Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida;
OC   Acanthamoebidae; Acanthamoeba.
OX   NCBI_TaxID=5755;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 30010 / Neff;
RX   PubMed=1408796; DOI=10.1093/nar/20.18.4817;
RA   Wong J.M., Liu F., Bateman E.;
RT   "Isolation of genomic DNA encoding transcription factor TFIID from
RT   Acanthamoeba castellanii: characterization of the promoter.";
RL   Nucleic Acids Res. 20:4817-4824(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ATCC 30010 / Neff;
RX   PubMed=1339370; DOI=10.1016/0378-1119(92)90494-a;
RA   Wong J.M., Liu F., Bateman E.;
RT   "Cloning and expression of the Acanthamoeba castellanii gene encoding
RT   transcription factor TFIID.";
RL   Gene 117:91-97(1992).
CC   -!- FUNCTION: General transcription factor that functions at the core of
CC       the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC       box is the initial transcriptional step of the pre-initiation complex
CC       (PIC), playing a role in the activation of eukaryotic genes transcribed
CC       by RNA polymerase II.
CC   -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC       factors (TAFs). Binds DNA as monomer.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; X63133; CAA44843.1; -; mRNA.
DR   EMBL; M93340; AAA27712.1; -; Genomic_DNA.
DR   EMBL; M87493; AAA27713.1; -; mRNA.
DR   PIR; JQ1666; JQ1666.
DR   AlphaFoldDB; P26354; -.
DR   SMR; P26354; -.
DR   VEuPathDB; AmoebaDB:ACA1_020820; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   CDD; cd04516; TBP_eukaryotes; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   InterPro; IPR033710; TBP_eukaryotic.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Repeat; Transcription.
FT   CHAIN           1..258
FT                   /note="TATA-box-binding protein"
FT                   /id="PRO_0000153969"
FT   REPEAT          85..161
FT                   /note="1"
FT   REPEAT          175..252
FT                   /note="2"
FT   REGION          19..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   258 AA;  28353 MW;  CADA4E34AB360742 CRC64;
     MSGITLPSLT NVLQSAGMAV HGHPSAPGST QLPPLHQLNI SSQPSSQPPQ PSLQYSEPAQ
     STAASDDMDS DVDRTKHPSG IVPTLQNIVS TVNLGCKLDL KNIALHARNA EYNPKRFAAV
     IMRIREPKTT ALIFASGKMV CTGAKSEEAS RLAARKYARI IQKLGFAAKF LDFKIQNIVG
     SCDVRFPIRL EGLAFAHNHY CSYEPELFPG LIYRMVQPKI VLLIFVSGKI VLTGAKVREE
     IYEAFENIYP VLTEYKKT
 
 
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