TBP_ACACA
ID TBP_ACACA Reviewed; 258 AA.
AC P26354;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=TATA sequence-binding protein;
DE Short=TBP;
DE AltName: Full=TATA-binding factor;
DE AltName: Full=TATA-box factor;
DE AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN Name=TFIID;
OS Acanthamoeba castellanii (Amoeba).
OC Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida;
OC Acanthamoebidae; Acanthamoeba.
OX NCBI_TaxID=5755;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 30010 / Neff;
RX PubMed=1408796; DOI=10.1093/nar/20.18.4817;
RA Wong J.M., Liu F., Bateman E.;
RT "Isolation of genomic DNA encoding transcription factor TFIID from
RT Acanthamoeba castellanii: characterization of the promoter.";
RL Nucleic Acids Res. 20:4817-4824(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ATCC 30010 / Neff;
RX PubMed=1339370; DOI=10.1016/0378-1119(92)90494-a;
RA Wong J.M., Liu F., Bateman E.;
RT "Cloning and expression of the Acanthamoeba castellanii gene encoding
RT transcription factor TFIID.";
RL Gene 117:91-97(1992).
CC -!- FUNCTION: General transcription factor that functions at the core of
CC the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC box is the initial transcriptional step of the pre-initiation complex
CC (PIC), playing a role in the activation of eukaryotic genes transcribed
CC by RNA polymerase II.
CC -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC factors (TAFs). Binds DNA as monomer.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR EMBL; X63133; CAA44843.1; -; mRNA.
DR EMBL; M93340; AAA27712.1; -; Genomic_DNA.
DR EMBL; M87493; AAA27713.1; -; mRNA.
DR PIR; JQ1666; JQ1666.
DR AlphaFoldDB; P26354; -.
DR SMR; P26354; -.
DR VEuPathDB; AmoebaDB:ACA1_020820; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Repeat; Transcription.
FT CHAIN 1..258
FT /note="TATA-box-binding protein"
FT /id="PRO_0000153969"
FT REPEAT 85..161
FT /note="1"
FT REPEAT 175..252
FT /note="2"
FT REGION 19..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 258 AA; 28353 MW; CADA4E34AB360742 CRC64;
MSGITLPSLT NVLQSAGMAV HGHPSAPGST QLPPLHQLNI SSQPSSQPPQ PSLQYSEPAQ
STAASDDMDS DVDRTKHPSG IVPTLQNIVS TVNLGCKLDL KNIALHARNA EYNPKRFAAV
IMRIREPKTT ALIFASGKMV CTGAKSEEAS RLAARKYARI IQKLGFAAKF LDFKIQNIVG
SCDVRFPIRL EGLAFAHNHY CSYEPELFPG LIYRMVQPKI VLLIFVSGKI VLTGAKVREE
IYEAFENIYP VLTEYKKT