TBP_BOMMO
ID TBP_BOMMO Reviewed; 307 AA.
AC O45211;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=TATA sequence-binding protein;
DE AltName: Full=TATA-binding factor;
DE AltName: Full=TATA-box factor;
DE AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN Name=Tbp;
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9795220; DOI=10.1016/s0378-1119(98)00460-0;
RA Ouyang C., Sprague K.U.;
RT "Cloning and characterization of the TATA-binding protein of the silkworm
RT Bombyx mori.";
RL Gene 221:207-213(1998).
CC -!- FUNCTION: General transcription factor that functions at the core of
CC the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC box is the initial transcriptional step of the pre-initiation complex
CC (PIC), playing a role in the activation of eukaryotic genes transcribed
CC by RNA polymerase II.
CC -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC factors (TAFs). Binds DNA as monomer.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P20226}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ222806; CAA11000.1; -; mRNA.
DR RefSeq; NP_001037059.1; NM_001043594.1.
DR AlphaFoldDB; O45211; -.
DR SMR; O45211; -.
DR STRING; 7091.BGIBMGA010619-TA; -.
DR EnsemblMetazoa; BGIBMGA010619-RA; BGIBMGA010619-TA; BGIBMGA010619.
DR GeneID; 692612; -.
DR KEGG; bmor:692612; -.
DR CTD; 6908; -.
DR eggNOG; KOG3302; Eukaryota.
DR HOGENOM; CLU_060161_1_3_1; -.
DR InParanoid; O45211; -.
DR OMA; HMMPMSE; -.
DR OrthoDB; 1219067at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISS:UniProtKB.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription.
FT CHAIN 1..307
FT /note="TATA-box-binding protein"
FT /id="PRO_0000153963"
FT REPEAT 134..210
FT /note="1"
FT REPEAT 224..301
FT /note="2"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 33989 MW; 3C3E5668807AD0EF CRC64;
MDHMLPSPYN IPGIGTPLHQ PEEDQQILPN AMQQQQLQQQ QSQAQPSLAA LGSSPIVGFG
AIMGTPQRSM HTYAPTASYA TPQQMMQPQT PQNMMSPMIA AGNLSSQQML SQASPAPMTP
LTPLSADPGI LPQLQNIVST VNLDCKLDLK KIALHARNAE YNPKRFAAVI MRIREPRTTA
LIFSSGKMVC TGAKSEEDSR LAARKYARII QKLGFTAKFL DFKIQNMVGS CDVKFPIRLE
GLVLTHGQFS SYEPELFPGL IYRMVKPRIV LLIFVSGKVV LTGAKVREEI YEAFDNIYPI
LKSFKKQ
