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TBP_BOVIN
ID   TBP_BOVIN               Reviewed;         319 AA.
AC   Q2HJ52;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=TATA-box-binding protein;
DE   AltName: Full=TATA sequence-binding protein;
DE   AltName: Full=TATA-binding factor;
DE   AltName: Full=TATA-box factor;
DE   AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN   Name=TBP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: General transcription factor that functions at the core of
CC       the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC       box is the initial transcriptional step of the pre-initiation complex
CC       (PIC), playing a role in the activation of eukaryotic genes transcribed
CC       by RNA polymerase II. Component of a BRF2-containing transcription
CC       factor complex that regulates transcription mediated by RNA polymerase
CC       III. Component of the transcription factor SL1/TIF-IB complex, which is
CC       involved in the assembly of the PIC (pre-initiation complex) during RNA
CC       polymerase I-dependent transcription. The rate of PIC formation
CC       probably is primarily dependent on the rate of association of SL1 with
CC       the rDNA promoter. SL1 is involved in stabilization of nucleolar
CC       transcription factor 1/UBTF on rDNA. {ECO:0000250|UniProtKB:P20226}.
CC   -!- SUBUNIT: Binds DNA as monomer. Belongs to the TFIID complex together
CC       with the TBP-associated factors (TAFs). Part of a TFIID-containing RNA
CC       polymerase II pre-initiation complex that is composed of TBP and at
CC       least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4,
CC       GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6,
CC       TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the
CC       transcription factor SL1/TIF-IB complex, composed of TBP and at least
CC       TAF1A, TAF1B, TAF1C and TAF1D. Association of TBP to form either TFIID
CC       or SL1/TIF-IB appears to be mutually exclusive. Interacts with TAF1A,
CC       TAF1B and TAF1C. Interacts with TFIIB, NCOA6, DRAP1, DR1 and ELF3.
CC       Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with UTF1.
CC       Interacts with BRF2; this interaction promotes recruitment of BRF2 to
CC       TATA box-containing promoters. Interacts with UBTF. Interacts with
CC       GPBP1. Interacts with CITED2. Interacts with ATF7IP. Interacts with
CC       LLPH. Interacts with GTF2B (via C-terminus); this interaction with
CC       promoter-bound TBP guides RNA polymerase II into the pre-initiation
CC       complex (PIC). Interacts with PAX5 (By similarity).
CC       {ECO:0000250|UniProtKB:P20226, ECO:0000250|UniProtKB:P29037}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P20226}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; BC113308; AAI13309.1; -; mRNA.
DR   RefSeq; NP_001069210.1; NM_001075742.1.
DR   AlphaFoldDB; Q2HJ52; -.
DR   SMR; Q2HJ52; -.
DR   STRING; 9913.ENSBTAP00000038800; -.
DR   PaxDb; Q2HJ52; -.
DR   Ensembl; ENSBTAT00000038996; ENSBTAP00000038800; ENSBTAG00000007686.
DR   GeneID; 516578; -.
DR   KEGG; bta:516578; -.
DR   CTD; 6908; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007686; -.
DR   eggNOG; KOG3302; Eukaryota.
DR   GeneTree; ENSGT00940000157474; -.
DR   InParanoid; Q2HJ52; -.
DR   OMA; FGRTNAS; -.
DR   OrthoDB; 1219067at2759; -.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000007686; Expressed in oocyte and 104 other tissues.
DR   GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005672; C:transcription factor TFIIA complex; IEA:Ensembl.
DR   GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR   GO; GO:0097550; C:transcription preinitiation complex; IEA:Ensembl.
DR   GO; GO:0017162; F:aryl hydrocarbon receptor binding; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISS:UniProtKB.
DR   GO; GO:0001093; F:TFIIB-class transcription factor binding; IEA:Ensembl.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:Ensembl.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR   CDD; cd04516; TBP_eukaryotes; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   InterPro; IPR033710; TBP_eukaryotic.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repeat; Transcription.
FT   CHAIN           1..319
FT                   /note="TATA-box-binding protein"
FT                   /id="PRO_0000268200"
FT   REPEAT          145..221
FT                   /note="1"
FT   REPEAT          235..312
FT                   /note="2"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..129
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   319 AA;  35219 MW;  9FA61A6A8E162C91 CRC64;
     MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQRQQQ
     QQQQQQQQQQ QQQQQQAAVA AVQQSTSQQA TQGPSGQTPQ LFHSQTLTTA PLPGTTPLYP
     SPMTPMTPIT PATPASESSG IVPQLQNIVS TVNLGCKLDL KTIALRARNA EYNPKRFAAV
     IMRIREPRTT ALIFSSGKMV CTGAKSEEQS RLAARKYARV VQKLGFPAKF LDFKIQNMVG
     SCDVKFPIRL EGLVLTHQQF SSYEPELFPG LIYRMIKPRI VLLIFVSGKV VLTGAKVRAE
     IYEAFENIYP ILKGFRKTT
 
 
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