TBP_CAEEL
ID TBP_CAEEL Reviewed; 340 AA.
AC P32085;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=TATA sequence-binding protein;
DE Short=TBP;
DE AltName: Full=TATA-binding factor;
DE Short=CeTBP {ECO:0000303|PubMed:11030349};
DE AltName: Full=TATA-box factor;
DE AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN Name=tbp-1; Synonyms=tbp; ORFNames=T20B12.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBUNIT.
RX PubMed=8415761; DOI=10.1073/pnas.90.20.9673;
RA Lichtsteiner S., Tjian R.;
RT "Cloning and properties of the Caenorhabditis elegans TATA-box-binding
RT protein.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:9673-9677(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Bristol N2;
RA Kohara Y., Shin-i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y.,
RA Thierry-Mieg D., Thierry-Mieg J.;
RT "The Caenorhabditis elegans transcriptome project, a complementary view of
RT the genome.";
RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP DEVELOPMENTAL STAGE, AND SUBCELLULAR LOCATION.
RX PubMed=11030349; DOI=10.1016/s1097-2765(00)00068-x;
RA Kaltenbach L., Horner M.A., Rothman J.H., Mango S.E.;
RT "The TBP-like factor CeTLF is required to activate RNA polymerase II
RT transcription during C. elegans embryogenesis.";
RL Mol. Cell 6:705-713(2000).
CC -!- FUNCTION: The TFIID basal transcription factor complex plays a major
CC role in the initiation of RNA polymerase II (Pol II)-dependent
CC transcription (By similarity). TFIID recognizes and binds promoters via
CC its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of
CC the pre-initiation complex (PIC) (By similarity). The TFIID complex
CC consists of tbp-1 and TBP-associated factors (TAFs) (By similarity).
CC General transcription factor that functions at the core of the TFIID
CC complex (PubMed:8415761). {ECO:0000250|UniProtKB:P20226,
CC ECO:0000269|PubMed:8415761}.
CC -!- SUBUNIT: Component of the TFIID basal transcription factor complex,
CC composed of TATA-box-binding protein tbp-1, and a number of TBP-
CC associated factors (TAFs) (By similarity). Binds DNA as monomer
CC (PubMed:8415761). {ECO:0000250|UniProtKB:P20226,
CC ECO:0000269|PubMed:8415761}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11030349}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the early embryo, in the germ line
CC and in all somatic nuclei beginning at the pronuclear stage.
CC {ECO:0000269|PubMed:11030349}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR EMBL; L07754; AAA03582.1; -; mRNA.
DR EMBL; FO081094; CCD69071.1; -; Genomic_DNA.
DR EMBL; AF303249; AAG50207.1; -; mRNA.
DR PIR; A48671; A48671.
DR RefSeq; NP_498635.1; NM_066234.5.
DR AlphaFoldDB; P32085; -.
DR SMR; P32085; -.
DR BioGRID; 41263; 21.
DR DIP; DIP-26447N; -.
DR IntAct; P32085; 8.
DR STRING; 6239.T20B12.2.2; -.
DR EPD; P32085; -.
DR PaxDb; P32085; -.
DR PeptideAtlas; P32085; -.
DR EnsemblMetazoa; T20B12.2.1; T20B12.2.1; WBGene00006542.
DR UCSC; T20B12.2.1; c. elegans.
DR WormBase; T20B12.2; CE01408; WBGene00006542; tbp-1.
DR eggNOG; KOG3302; Eukaryota.
DR GeneTree; ENSGT00940000167740; -.
DR HOGENOM; CLU_060161_1_3_1; -.
DR InParanoid; P32085; -.
DR OMA; SMQMHSH; -.
DR OrthoDB; 1219067at2759; -.
DR PhylomeDB; P32085; -.
DR Reactome; R-CEL-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-CEL-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-CEL-73772; RNA Polymerase I Promoter Escape.
DR Reactome; R-CEL-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-CEL-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-CEL-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-CEL-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Reactome; R-CEL-9018519; Estrogen-dependent gene expression.
DR SignaLink; P32085; -.
DR PRO; PR:P32085; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00006542; Expressed in embryo and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:WormBase.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; IDA:WormBase.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISS:UniProtKB.
DR GO; GO:0008134; F:transcription factor binding; IPI:WormBase.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:WormBase.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription.
FT CHAIN 1..340
FT /note="TATA-box-binding protein"
FT /id="PRO_0000153970"
FT REPEAT 168..244
FT /note="1"
FT REPEAT 258..335
FT /note="2"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 340 AA; 36647 MW; B3127075BC6998CB CRC64;
MNLNSPAVSM LGGDTPAHGG PNSVLGGQGP SSILTGHGPN SVMGPNSILG PGSVLNPQSI
QPMQSQQMHS LQGSSMQMHS HLANSNLNLN INPASVGPDR NPGSVMHHNL DINPPSVAYQ
NLTVPMTPLA YSVYDRDALT HQAPASNIAA TMVPATPASQ LDIPMPALQN IVSTVNLGVQ
LDLKKIALHA RNAEYNPKRF AAVIMRIREP RTTALIFSSG KMVCTGAKSE EASRLAARKY
ARIVQKLGFQ AKFTEFMVQN MVGSCDVRFP IQLEGLCITH SQFSTYEPEL FPGLIYRMVK
PRVVLLIFVS GKVVITGAKT KRDIDEAFGQ IYPILKGFKK
