TBP_CANAL
ID TBP_CANAL Reviewed; 238 AA.
AC O43133; A0A1D8PEW8; Q59LW4;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=TATA sequence-binding protein;
DE Short=TBP;
DE AltName: Full=TATA-binding factor;
DE AltName: Full=TATA-box factor;
DE AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN Name=TBP1; Synonyms=TBP; OrderedLocusNames=CAALFM_C110660WA;
GN ORFNames=CaO19.1837, CaO19.9395;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=ATCC 10261 / 3153;
RX PubMed=9537374; DOI=10.1128/jb.180.7.1771-1776.1998;
RA Leng P., Carter P.E., Brown A.J.P.;
RT "The TATA-binding protein (TBP) from the human fungal pathogen Candida
RT albicans can complement defects in human and yeast TBPs.";
RL J. Bacteriol. 180:1771-1776(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: General transcription factor that functions at the core of
CC the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC box is the initial transcriptional step of the pre-initiation complex
CC (PIC), playing a role in the activation of eukaryotic genes transcribed
CC by RNA polymerase II.
CC -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC factors (TAFs). Binds DNA as monomer.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U95550; AAC49986.1; -; mRNA.
DR EMBL; U95549; AAC49985.1; -; Genomic_DNA.
DR EMBL; CP017623; AOW26693.1; -; Genomic_DNA.
DR RefSeq; XP_710721.1; XM_705629.1.
DR AlphaFoldDB; O43133; -.
DR SMR; O43133; -.
DR BioGRID; 1230734; 1.
DR STRING; 237561.O43133; -.
DR GeneID; 3647675; -.
DR KEGG; cal:CAALFM_C110660WA; -.
DR CGD; CAL0000189736; TBP1.
DR VEuPathDB; FungiDB:C1_10660W_A; -.
DR eggNOG; KOG3302; Eukaryota.
DR HOGENOM; CLU_060161_4_2_1; -.
DR InParanoid; O43133; -.
DR OMA; FHFKIAD; -.
DR OrthoDB; 1219067at2759; -.
DR PRO; PR:O43133; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0000120; C:RNA polymerase I transcription regulator complex; IEA:EnsemblFungi.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:EnsemblFungi.
DR GO; GO:0005667; C:transcription regulator complex; IGI:CGD.
DR GO; GO:0003677; F:DNA binding; IDA:CGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IGI:CGD.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:EnsemblFungi.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0001006; F:RNA polymerase III type 3 promoter sequence-specific DNA binding; IEA:EnsemblFungi.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR GO; GO:0006361; P:transcription initiation from RNA polymerase I promoter; IEA:EnsemblFungi.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IGI:CGD.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription.
FT CHAIN 1..238
FT /note="TATA-box-binding protein"
FT /id="PRO_0000153987"
FT REPEAT 65..141
FT /note="1"
FT REPEAT 155..232
FT /note="2"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 238 AA; 26601 MW; CA0C3F666FBF20FE CRC64;
MDLKLPPTNP TNPQQAKTFM KSIEEDEKNK AEDLDIIKKE DIDEPKQEDT TDGNGGGGIG
IVPTLQNIVA TVNLDCRLDL KTIALHARNA EYNPKRFAAV IMRIRDPKTT ALIFASGKMV
VTGAKSEDDS KLASRKYARI IQKLGFNAKF CDFKIQNIVG STDVKFAIRL EGLAFAHGTF
SSYEPELFPG LIYRMVKPKI VLLIFVSGKI VLTGAKKREE IYDAFESIYP VLNEFRKN
