TBP_CHICK
ID TBP_CHICK Reviewed; 302 AA.
AC O13270;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=TATA sequence-binding protein;
DE AltName: Full=TATA-binding factor;
DE AltName: Full=TATA-box factor;
DE AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN Name=TBP;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Liver;
RX PubMed=9177284; DOI=10.1006/bbrc.1997.6653;
RA Yamauchi J., Sugita A., Fujiwara M., Suzuki K., Matsumoto H., Yamazaki T.,
RA Ninomiya Y., Ono T., Hasegawa T., Masushige S., Muramatsu M., Tamura T.,
RA Kato S.;
RT "Two forms of avian(chicken) TATA-binding protein mRNA generated by
RT alternative polyadenylation.";
RL Biochem. Biophys. Res. Commun. 234:406-411(1997).
CC -!- FUNCTION: General transcription factor that functions at the core of
CC the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC box is the initial transcriptional step of the pre-initiation complex
CC (PIC), playing a role in the activation of eukaryotic genes transcribed
CC by RNA polymerase II.
CC -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC factors (TAFs). Binds DNA as monomer. {ECO:0000250|UniProtKB:P20226}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P20226}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR EMBL; D83127; BAA20297.1; -; mRNA.
DR EMBL; D83126; BAA20296.1; -; mRNA.
DR EMBL; D83135; BAA20298.1; -; Genomic_DNA.
DR PIR; JC5513; JC5513.
DR RefSeq; NP_990434.1; NM_205103.1.
DR AlphaFoldDB; O13270; -.
DR SMR; O13270; -.
DR STRING; 9031.ENSGALP00000036925; -.
DR PaxDb; O13270; -.
DR GeneID; 395995; -.
DR KEGG; gga:395995; -.
DR CTD; 6908; -.
DR VEuPathDB; HostDB:geneid_395995; -.
DR eggNOG; KOG3302; Eukaryota.
DR InParanoid; O13270; -.
DR OrthoDB; 1219067at2759; -.
DR PhylomeDB; O13270; -.
DR PRO; PR:O13270; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISS:UniProtKB.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription.
FT CHAIN 1..302
FT /note="TATA-box-binding protein"
FT /id="PRO_0000153959"
FT REPEAT 128..204
FT /note="1"
FT REPEAT 218..295
FT /note="2"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..112
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 302 AA; 33134 MW; 1BEB9EB846F13ACA CRC64;
MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPVQSTNSLS ILEEQQRQQQ
QQQAAQSSTS QQATQGTSGQ TPQLFHSQTL TTAPLPGTTP LYPSPMTPMT PITPATPASE
SSGIVPQLQN IVSTVNLGCK LDLKTIALRA RNAEYNPKRF AAVIMRIREP RTTALIFSSG
KMVCTGAKSE EQSRLAARKY ARVVQKLGFP AKFLDFKIQN MVGSCDVKFP IRLEGLVLTH
QQFSSYEPEL FPGLIYRMIK PRIVLLIFVS GKVVLTGAKV RAEIYEAFEN IYPILKGFRK
TT
