TBP_DANRE
ID TBP_DANRE Reviewed; 302 AA.
AC Q7SXL3; Q71H62;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=TATA-box-binding protein {ECO:0000312|ZFIN:ZDB-GENE-030616-563};
DE Short=zTBP {ECO:0000303|PubMed:11250159};
DE AltName: Full=TATA sequence-binding protein {ECO:0000250|UniProtKB:P20226};
DE AltName: Full=TATA-binding factor {ECO:0000250|UniProtKB:P20226};
DE AltName: Full=TATA-box factor {ECO:0000250|UniProtKB:P20226};
DE Short=zfTBF {ECO:0000303|PubMed:12885957};
DE AltName: Full=Transcription initiation factor TFIID TBP subunit {ECO:0000250|UniProtKB:P20226};
GN Name=tbp {ECO:0000312|ZFIN:ZDB-GENE-030616-563};
GN ORFNames=si:ch211-202m22.5;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|EMBL:AAO34524.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12885957; DOI=10.1093/molbev/msg205;
RA Bondareva A.A., Schmidt E.E.;
RT "Early vertebrate evolution of the TATA-binding protein, TBP.";
RL Mol. Biol. Evol. 20:1932-1939(2003).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAQ07596.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Gonad {ECO:0000312|EMBL:AAQ07596.1};
RX PubMed=15062100; DOI=10.1016/j.cub.2004.03.034;
RA Bartfai R., Balduf C., Hilton T., Rathmann Y., Hadzhiev Y., Tora L.,
RA Orban L., Mueller F.;
RT "TBP2, a vertebrate-specific member of the TBP family, is required in
RT embryonic development of zebrafish.";
RL Curr. Biol. 14:593-598(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000312|EMBL:CAK04406.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=SJD {ECO:0000312|EMBL:AAH55549.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP FUNCTION.
RX PubMed=11250159; DOI=10.1016/s0960-9822(01)00076-8;
RA Mueller F., Lakatos L., Dantonel J.-C., Straehle U., Tora L.;
RT "TBP is not universally required for zygotic RNA polymerase II
RT transcription in zebrafish.";
RL Curr. Biol. 11:282-287(2001).
RN [6] {ECO:0000305}
RP FUNCTION.
RX PubMed=17703193; DOI=10.1038/sj.emboj.7601821;
RA Ferg M., Sanges R., Gehrig J., Kiss J., Bauer M., Lovas A., Szabo M.,
RA Yang L., Straehle U., Pankratz M.J., Olasz F., Stupka E., Mueller F.;
RT "The TATA-binding protein regulates maternal mRNA degradation and
RT differential zygotic transcription in zebrafish.";
RL EMBO J. 26:3945-3956(2007).
RN [7] {ECO:0000305}
RP FUNCTION.
RX PubMed=18046332; DOI=10.1038/nature06349;
RA Hart D.O., Raha T., Lawson N.D., Green M.R.;
RT "Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-
RT related factor Trf3.";
RL Nature 450:1082-1085(2007).
CC -!- FUNCTION: General transcription factor that functions at the core of
CC the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC box is the initial transcriptional step of the pre-initiation complex
CC (PIC), playing a role in the activation of eukaryotic genes transcribed
CC by RNA polymerase II (By similarity). Members of the TBP family are
CC differentially required for transcription and development during early
CC embryogenesis. Regulates mRNA levels in the early embryo by both
CC transcriptional and post-transcriptional mechanisms. Required for
CC transcription of a subset of genes at the mid-blastula transition
CC (MBT). Negatively regulates the expression of other embryonic genes,
CC including autoregulation of the tbp promoter itself. Also functions
CC within a transcription-dependent mechanism to direct the temporally-
CC regulated degradation of a subset of maternal mRNAs after the MBT. This
CC is part of a general mechanism to regulate the maternal to zygotic
CC transition and is required for normal embryonic development. Binds to
CC promoters of a subset of genes. Required for gastrulation.
CC {ECO:0000250|UniProtKB:P20226, ECO:0000269|PubMed:11250159,
CC ECO:0000269|PubMed:17703193, ECO:0000269|PubMed:18046332}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P20226}.
CC -!- TISSUE SPECIFICITY: Enriched in testis but hardly detectable in the
CC ovary (at protein level). {ECO:0000269|PubMed:15062100}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Expression is very low in the zygote, increasing from morula stage
CC onward to reach a peak during early gastrulation. Levels then rapidly
CC decline during neurula and organogenesis stages (at protein level).
CC There is an inverse correlation between mRNA and protein levels at the
CC late blastula and early gastrula stages. {ECO:0000269|PubMed:15062100}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255}.
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DR EMBL; AY168633; AAO34524.1; -; mRNA.
DR EMBL; AF503449; AAQ07596.1; -; mRNA.
DR EMBL; AL772388; CAK04406.1; -; Genomic_DNA.
DR EMBL; BC055549; AAH55549.1; -; mRNA.
DR EMBL; BC065860; AAH65860.1; -; mRNA.
DR RefSeq; NP_956390.1; NM_200096.1.
DR AlphaFoldDB; Q7SXL3; -.
DR SMR; Q7SXL3; -.
DR STRING; 7955.ENSDARP00000010211; -.
DR PaxDb; Q7SXL3; -.
DR Ensembl; ENSDART00000016211; ENSDARP00000010211; ENSDARG00000014994.
DR Ensembl; ENSDART00000181093; ENSDARP00000154436; ENSDARG00000014994.
DR GeneID; 368882; -.
DR KEGG; dre:368882; -.
DR CTD; 6908; -.
DR ZFIN; ZDB-GENE-030616-563; tbp.
DR eggNOG; KOG3302; Eukaryota.
DR GeneTree; ENSGT00940000157474; -.
DR HOGENOM; CLU_060161_1_1_1; -.
DR InParanoid; Q7SXL3; -.
DR OMA; FGRTNAS; -.
DR OrthoDB; 1219067at2759; -.
DR PhylomeDB; Q7SXL3; -.
DR TreeFam; TF300102; -.
DR Reactome; R-DRE-5250924; B-WICH complex positively regulates rRNA expression.
DR Reactome; R-DRE-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-DRE-6804756; Regulation of TP53 Activity through Phosphorylation.
DR Reactome; R-DRE-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-DRE-73762; RNA Polymerase I Transcription Initiation.
DR Reactome; R-DRE-73772; RNA Polymerase I Promoter Escape.
DR Reactome; R-DRE-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-DRE-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-DRE-73863; RNA Polymerase I Transcription Termination.
DR Reactome; R-DRE-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-DRE-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Reactome; R-DRE-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-DRE-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR Reactome; R-DRE-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR Reactome; R-DRE-9018519; Estrogen-dependent gene expression.
DR PRO; PR:Q7SXL3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 13.
DR Bgee; ENSDARG00000014994; Expressed in cleaving embryo and 29 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISS:UniProtKB.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; ISS:ZFIN.
DR GO; GO:0007369; P:gastrulation; IMP:UniProtKB.
DR GO; GO:0006402; P:mRNA catabolic process; IMP:UniProtKB.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Gastrulation; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..302
FT /note="TATA-box-binding protein"
FT /id="PRO_0000348608"
FT REPEAT 128..204
FT /note="1"
FT /evidence="ECO:0000255"
FT REPEAT 218..295
FT /note="2"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 184
FT /note="C -> G (in Ref. 2; AAQ07596)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 302 AA; 33019 MW; C63A6C1D2F7E1D50 CRC64;
MEQNNSLPPF AQGLASPQGA MTPGLPIFSP MMPYGTGLTP QPVQNSNSLS LLEEQQRQQQ
QQQAASQQQG GMVGGSGQTP QLYHSTQAVS TTTALPGNTP LYTTPLTPMT PITPATPASE
SSGIVPQLQN IVSTVNLGCK LDLKTIALRA RNAEYNPKRF AAVIMRIREP RTTALIFSSG
KMVCTGAKSE EQSRLAARKY ARVVQKLGFP AKFLDFKIQN MVGSCDVKFP IRLEGLVLTH
QQFSSYEPEL FPGLIYRMIK PRIVLLIFVS GKVVLTGAKV RGEIYEAFEN IYPILKGFRK
TS
