TBP_DICDI
ID TBP_DICDI Reviewed; 205 AA.
AC P26355; Q552P8; Q75K25;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=TATA sequence-binding protein;
DE Short=TBP;
DE AltName: Full=TATA-binding factor;
DE AltName: Full=TATA-box factor;
DE AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN Name=tbpA; Synonyms=tfdA; ORFNames=DDB_G0275617;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX4;
RA Blume J.E., Shaw D.R., Ennis H.L.;
RT "Dictyostelium TFIID mRNA is developmentally regulated.";
RL Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: General transcription factor that functions at the core of
CC the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC box is the initial transcriptional step of the pre-initiation complex
CC (PIC), playing a role in the activation of eukaryotic genes transcribed
CC by RNA polymerase II.
CC -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC factors (TAFs). Binds DNA as monomer.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR EMBL; M64861; AAA33256.1; -; mRNA.
DR EMBL; AAFI02000013; EAL69559.1; -; Genomic_DNA.
DR RefSeq; XP_643633.1; XM_638541.1.
DR AlphaFoldDB; P26355; -.
DR SMR; P26355; -.
DR STRING; 44689.DDB0185066; -.
DR PaxDb; P26355; -.
DR EnsemblProtists; EAL69559; EAL69559; DDB_G0275617.
DR GeneID; 8620220; -.
DR KEGG; ddi:DDB_G0275617; -.
DR dictyBase; DDB_G0275617; tbpA.
DR eggNOG; KOG3302; Eukaryota.
DR HOGENOM; CLU_060161_4_2_1; -.
DR InParanoid; P26355; -.
DR OMA; NCEYEPE; -.
DR PhylomeDB; P26355; -.
DR Reactome; R-DDI-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-DDI-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-DDI-73772; RNA Polymerase I Promoter Escape.
DR Reactome; R-DDI-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-DDI-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-DDI-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-DDI-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Reactome; R-DDI-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-DDI-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR PRO; PR:P26355; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IC:dictyBase.
DR GO; GO:0000126; C:transcription factor TFIIIB complex; IDA:dictyBase.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:dictyBase.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:dictyBase.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; ISS:dictyBase.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription.
FT CHAIN 1..205
FT /note="TATA-box-binding protein"
FT /id="PRO_0000153971"
FT REPEAT 27..103
FT /note="1"
FT REPEAT 117..194
FT /note="2"
FT CONFLICT 41
FT /note="D -> Y (in Ref. 1; AAA33256)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="V -> L (in Ref. 1; AAA33256)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="E -> Y (in Ref. 1; AAA33256)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 205 AA; 22799 MW; A4992B882CEF96AB CRC64;
MSTATTTSTP AQNVDLSKHP SGIIPTLQNI VSTVNMATEL DLKAIALGAR NAEYNPKRFA
AVIMRIREPK TTALIFKSGK MVCTGAKSED ASRFAARKYA RIIQKLDFPA RFTDFKIQNI
VGSCDVKFPI KLELLHNAHT SFTNYEPEIF PGLIYKMIQP KVVLLIFVSG KIVLTGAKVR
EEIYEAFENI YPVLSAFKKV NAITQ
