TBP_DROVI
ID TBP_DROVI Reviewed; 349 AA.
AC Q9NHP5;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=TATA sequence-binding protein;
DE AltName: Full=TATA-binding factor;
DE AltName: Full=TATA-box factor;
DE AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN Name=Tbp;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Oh Y., Baek K., Yoon J.;
RT "Structure of Drosophila virilis TBP and TFIIB genes and comparison with
RT the Drosophila melanogaster genes.";
RL Korean J. Genet. 21:299-305(1999).
CC -!- FUNCTION: General transcription factor that functions at the core of
CC the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC box is the initial transcriptional step of the pre-initiation complex
CC (PIC), playing a role in the activation of eukaryotic genes transcribed
CC by RNA polymerase II. {ECO:0000250|UniProtKB:P20227}.
CC -!- SUBUNIT: Belongs to the TFIID complex which is composed of TATA binding
CC protein (Tbp) and a number of TBP-associated factors (Tafs). Binds DNA
CC as monomer. Interacts with TFIIA-L heterotrimer. Interacts with Taf1,
CC Taf2, Taf5 and Taf12. {ECO:0000250|UniProtKB:P20227}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P20226}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR EMBL; AF220262; AAF71711.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9NHP5; -.
DR SMR; Q9NHP5; -.
DR STRING; 7244.FBpp0229334; -.
DR eggNOG; KOG3302; Eukaryota.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISS:UniProtKB.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 1.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Repeat; Transcription.
FT CHAIN 1..349
FT /note="TATA-box-binding protein"
FT /id="PRO_0000153965"
FT REPEAT 175..251
FT /note="1"
FT REPEAT 265..342
FT /note="2"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 42..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 349 AA; 38258 MW; 3D2B5A13A56A753A CRC64;
MDDIMSPNFS IPSIGHAPTP IHHSLDADQQ IEALPHQVYH PAALDPTPTA TTTVQQQQQP
DGNNGVSAAD GSGGSNLFGH EPSIPLAHKQ SYQPSASYQQ QQQQQQNQSS NTGGTTPQSL
MQPQTPQSMM SHMMPMTSAA PPDASLSNIH QTMGPSTPMT PATPGSADPG IVPQLQNIVS
TVNLCCKLDL KKIALHARNA EYNPKRFAPV IMRIREPRTT ALIFSSGKMV CTGAKGEDDS
RLAARKYARI IQKLGFRAKF LDLKIQNMVG LCDVKFPIRL EGLVLTHCNF SRYEPELFPG
LIYRMVRPRI VLLLPAPGKV VLTGAKVRQE IYDAFDKIFS ILKKFKKQS
