TBP_MESAU
ID TBP_MESAU Reviewed; 318 AA.
AC P53360;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=TATA sequence-binding protein;
DE AltName: Full=TATA-binding factor;
DE AltName: Full=TATA-box factor;
DE AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN Name=TBP; Synonyms=TFIID;
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RA Noguchi E.;
RT "The minimum essential region of CCG1/TAF250 required for promoter-
RT selective transcription with TFIID complex.";
RL Thesis (1994), Kyushu University / Fukuoka, Japan.
CC -!- FUNCTION: General transcription factor that functions at the core of
CC the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC box is the initial transcriptional step of the pre-initiation complex
CC (PIC), playing a role in the activation of eukaryotic genes transcribed
CC by RNA polymerase II. Component of a BRF2-containing transcription
CC factor complex that regulates transcription mediated by RNA polymerase
CC III. Component of the transcription factor SL1/TIF-IB complex, which is
CC involved in the assembly of the PIC (pre-initiation complex) during RNA
CC polymerase I-dependent transcription. The rate of PIC formation
CC probably is primarily dependent on the rate of association of SL1 with
CC the rDNA promoter. SL1 is involved in stabilization of nucleolar
CC transcription factor 1/UBTF on rDNA. {ECO:0000250|UniProtKB:P20226}.
CC -!- SUBUNIT: Binds DNA as monomer. Belongs to the TFIID complex together
CC with the TBP-associated factors (TAFs). Part of a TFIID-containing RNA
CC polymerase II pre-initiation complex that is composed of TBP and at
CC least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4,
CC GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6,
CC TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the
CC transcription factor SL1/TIF-IB complex, composed of TBP and at least
CC TAF1A, TAF1B, TAF1C and TAF1D. Association of TBP to form either TFIID
CC or SL1/TIF-IB appears to be mutually exclusive. Interacts with TAF1A,
CC TAF1B and TAF1C. Interacts with TFIIB, NCOA6, DRAP1, DR1 and ELF3.
CC Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with UTF1.
CC Interacts with BRF2; this interaction promotes recruitment of BRF2 to
CC TATA box-containing promoters. Interacts with UBTF. Interacts with
CC GPBP1. Interacts with CITED2. Interacts with ATF7IP. Interacts with
CC LLPH. Interacts with HSF1 (via transactivation domain). Interacts with
CC GTF2B (via C-terminus); this interaction with promoter-bound TBP guides
CC RNA polymerase II into the pre-initiation complex (PIC). Interacts with
CC PAX5 (By similarity). {ECO:0000250|UniProtKB:P20226,
CC ECO:0000250|UniProtKB:P29037}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P20226}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR EMBL; D30051; BAA06287.1; -; mRNA.
DR RefSeq; NP_001268562.1; NM_001281633.1.
DR AlphaFoldDB; P53360; -.
DR SMR; P53360; -.
DR STRING; 10036.XP_005083081.1; -.
DR GeneID; 101839769; -.
DR CTD; 6908; -.
DR eggNOG; KOG3302; Eukaryota.
DR OrthoDB; 1219067at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001091; F:RNA polymerase II general transcription initiation factor binding; IPI:BHF-UCL.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISS:UniProtKB.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription.
FT CHAIN 1..318
FT /note="TATA-box-binding protein"
FT /id="PRO_0000153957"
FT REPEAT 144..220
FT /note="1"
FT REPEAT 234..311
FT /note="2"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..128
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 318 AA; 34956 MW; A25FCD27A6422593 CRC64;
MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQREQQ
QQQQQQQQQQ QQAVATAAAS VQQSTSQQST QGASGQTPQL FHSQTLTTAP LPGTTPLYPS
PMTPMTPITP ATPASESSGI VPQLQNIVST VNLGCKLDLK TIALRARNAE YNPKRFAAVI
MRIREPRTTA LIFSSGKMVC TGAKSEEQSR LAARKYARVV QKLGFPAKFL DFKIQNMVGS
CDVKFPIRLE GLVLTHQQFS SYEPELFPGL IYRMIKPRIV LLIFVSGKVV LTGAKVRAEI
YEAFENIYPI LKGFRKTT
