TBP_METJA
ID TBP_METJA Reviewed; 183 AA.
AC Q57930;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=Box A-binding protein;
DE Short=BAP;
DE AltName: Full=TATA sequence-binding protein;
DE Short=TBP;
DE AltName: Full=TATA-box factor;
GN Name=tbp; OrderedLocusNames=MJ0507;
OS Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS 10045 / NBRC 100440) (Methanococcus jannaschii).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=243232;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 4-183.
RX PubMed=19090808; DOI=10.1111/j.1365-2443.2008.01233.x;
RA Adachi N., Senda M., Natsume R., Senda T., Horikoshi M.;
RT "Crystal structure of Methanococcus jannaschii TATA box-binding protein.";
RL Genes Cells 13:1127-1140(2008).
CC -!- FUNCTION: General factor that plays a role in the activation of
CC archaeal genes transcribed by RNA polymerase. Binds specifically to the
CC TATA box promoter element which lies close to the position of
CC transcription initiation (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L77117; AAB98497.1; -; Genomic_DNA.
DR PIR; C64363; C64363.
DR PDB; 2Z8U; X-ray; 1.90 A; A/B/P/Q=4-183.
DR PDBsum; 2Z8U; -.
DR AlphaFoldDB; Q57930; -.
DR SMR; Q57930; -.
DR STRING; 243232.MJ_0507; -.
DR PRIDE; Q57930; -.
DR EnsemblBacteria; AAB98497; AAB98497; MJ_0507.
DR KEGG; mja:MJ_0507; -.
DR eggNOG; arCOG01764; Archaea.
DR HOGENOM; CLU_060161_4_3_2; -.
DR InParanoid; Q57930; -.
DR OMA; NCEYEPE; -.
DR PhylomeDB; Q57930; -.
DR EvolutionaryTrace; Q57930; -.
DR Proteomes; UP000000805; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR CDD; cd04518; TBP_archaea; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR033711; TBP_archaea.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..183
FT /note="TATA-box-binding protein"
FT /id="PRO_0000154008"
FT REPEAT 10..86
FT /note="1"
FT REPEAT 101..177
FT /note="2"
FT STRAND 9..18
FT /evidence="ECO:0007829|PDB:2Z8U"
FT HELIX 25..31
FT /evidence="ECO:0007829|PDB:2Z8U"
FT TURN 39..41
FT /evidence="ECO:0007829|PDB:2Z8U"
FT STRAND 45..49
FT /evidence="ECO:0007829|PDB:2Z8U"
FT TURN 50..53
FT /evidence="ECO:0007829|PDB:2Z8U"
FT STRAND 54..58
FT /evidence="ECO:0007829|PDB:2Z8U"
FT STRAND 62..71
FT /evidence="ECO:0007829|PDB:2Z8U"
FT HELIX 72..88
FT /evidence="ECO:0007829|PDB:2Z8U"
FT STRAND 100..109
FT /evidence="ECO:0007829|PDB:2Z8U"
FT HELIX 116..122
FT /evidence="ECO:0007829|PDB:2Z8U"
FT STRAND 126..128
FT /evidence="ECO:0007829|PDB:2Z8U"
FT TURN 130..132
FT /evidence="ECO:0007829|PDB:2Z8U"
FT STRAND 133..140
FT /evidence="ECO:0007829|PDB:2Z8U"
FT TURN 141..144
FT /evidence="ECO:0007829|PDB:2Z8U"
FT STRAND 145..149
FT /evidence="ECO:0007829|PDB:2Z8U"
FT STRAND 153..159
FT /evidence="ECO:0007829|PDB:2Z8U"
FT HELIX 163..180
FT /evidence="ECO:0007829|PDB:2Z8U"
SQ SEQUENCE 183 AA; 20233 MW; 3C648FA0FC404944 CRC64;
MKIMEPEIKI VNVVVSTKIG DNIDLEEVAM ILENAEYEPE QFPGLVCRLS VPKVALLIFR
SGKVNCTGAK SKEEAEIAIK KIIKELKDAG IDVIENPEIK IQNMVATADL GIEPNLDDIA
LMVEGTEYEP EQFPGLVYRL DDPKVVVLIF GSGKVVITGL KSEEDAKRAL KKILDTIKEV
QEL
