TBP_METKA
ID TBP_METKA Reviewed; 185 AA.
AC Q8TX38;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=TATA-box-binding protein {ECO:0000255|HAMAP-Rule:MF_00408};
DE AltName: Full=Box A-binding protein {ECO:0000255|HAMAP-Rule:MF_00408};
DE Short=BAP {ECO:0000255|HAMAP-Rule:MF_00408};
DE AltName: Full=TATA sequence-binding protein {ECO:0000255|HAMAP-Rule:MF_00408};
DE Short=TBP {ECO:0000255|HAMAP-Rule:MF_00408};
DE AltName: Full=TATA-box factor {ECO:0000255|HAMAP-Rule:MF_00408};
GN Name=tbp {ECO:0000255|HAMAP-Rule:MF_00408}; OrderedLocusNames=MK0839;
OS Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC Methanopyrus.
OX NCBI_TaxID=190192;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX PubMed=11930014; DOI=10.1073/pnas.032671499;
RA Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA Koonin E.V., Kozyavkin S.A.;
RT "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT monophyly of archaeal methanogens.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC -!- FUNCTION: General factor that plays a role in the activation of
CC archaeal genes transcribed by RNA polymerase. Binds specifically to the
CC TATA box promoter element which lies close to the position of
CC transcription initiation. {ECO:0000255|HAMAP-Rule:MF_00408}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255|HAMAP-
CC Rule:MF_00408}.
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DR EMBL; AE009439; AAM02052.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8TX38; -.
DR SMR; Q8TX38; -.
DR STRING; 190192.MK0839; -.
DR EnsemblBacteria; AAM02052; AAM02052; MK0839.
DR KEGG; mka:MK0839; -.
DR PATRIC; fig|190192.8.peg.882; -.
DR HOGENOM; CLU_060161_4_3_2; -.
DR OMA; NCEYEPE; -.
DR Proteomes; UP000001826; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR10126; PTHR10126; 2.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..185
FT /note="TATA-box-binding protein"
FT /id="PRO_0000154009"
FT REPEAT 3..78
FT /note="1"
FT REPEAT 94..176
FT /note="2"
SQ SEQUENCE 185 AA; 20730 MW; 986CDA328B72E1B3 CRC64;
MEIQNIVASV DLKGEVNLDE CSVILQGEYE PEQFPGLVYR LEDIGTVVLI FRSGKMVCTG
AKNREQIYKS VERVREDLEK KCGVKFHGEP EVEIQNIVAS IDFHVPLDLD TIAEVLVGDE
DVEGIEYEPE QFPGLVLRLR EPKVAMLLFY SGKAVCTGAK TEEEPEKAVK KIAEKIEKYG
LKLTG