ID   TBP_METTL               Reviewed;         181 AA.
AC   Q9P9I9;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=TATA-box-binding protein;
DE   AltName: Full=Box A-binding protein;
DE            Short=BAP;
DE   AltName: Full=TATA sequence-binding protein;
DE            Short=TBP;
DE   AltName: Full=TATA-box factor;
DE   AltName: Full=aTBP;
GN   Name=tbp;
OS   Methanothermococcus thermolithotrophicus (Methanococcus
OS   thermolithotrophicus).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanothermococcus.
OX   NCBI_TaxID=2186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10777522; DOI=10.1074/jbc.275.17.12393;
RA   Hausner W., Lange U., Musfeldt M.;
RT   "Transcription factor S, a cleavage induction factor of the archaeal RNA
RT   polymerase.";
RL   J. Biol. Chem. 275:12393-12399(2000).
CC   -!- FUNCTION: General factor that plays a role in the activation of
CC       archaeal genes transcribed by RNA polymerase. Binds specifically to the
CC       TATA box promoter element which lies close to the position of
CC       transcription initiation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; AJ271331; CAB66385.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9P9I9; -.
DR   SMR; Q9P9I9; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   CDD; cd04518; TBP_archaea; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR033711; TBP_archaea.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   3: Inferred from homology;
KW   DNA-binding; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..181
FT                   /note="TATA-box-binding protein"
FT                   /id="PRO_0000154015"
FT   REPEAT          7..83
FT                   /note="1"
FT   REPEAT          98..173
FT                   /note="2"
SQ   SEQUENCE   181 AA;  20008 MW;  B0175C0236E94B42 CRC64;
     MEPEIKIVNV VVSTQIGTDI DLEYAADILD NAEYEPEQFP GLVCRLSDPK VALLIFRSGK
     LNCTGAKSKE DAEIAIKKII KELKDAGMDI IDNPEVNVQN MVATADLGIE PNLDDISTLE
     GTEYEPEQFP GLVYRLSDPK VVVLIFGSGK VVITGLKKKD DAYLALDKIL STLKELEEEY
     Y