ID   TBP_NATPD               Reviewed;         187 AA.
AC   Q3ITB1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=TATA-box-binding protein {ECO:0000255|HAMAP-Rule:MF_00408};
DE   AltName: Full=Box A-binding protein {ECO:0000255|HAMAP-Rule:MF_00408};
DE            Short=BAP {ECO:0000255|HAMAP-Rule:MF_00408};
DE   AltName: Full=TATA sequence-binding protein {ECO:0000255|HAMAP-Rule:MF_00408};
DE            Short=TBP {ECO:0000255|HAMAP-Rule:MF_00408};
DE   AltName: Full=TATA-box factor {ECO:0000255|HAMAP-Rule:MF_00408};
GN   Name=tbp {ECO:0000255|HAMAP-Rule:MF_00408}; OrderedLocusNames=NP_1064A;
OS   Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM
OS   8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Natronomonas.
OX   NCBI_TaxID=348780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB
RC   2260 / Gabara;
RX   PubMed=16169924; DOI=10.1101/gr.3952905;
RA   Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA   Oesterhelt D.;
RT   "Living with two extremes: conclusions from the genome sequence of
RT   Natronomonas pharaonis.";
RL   Genome Res. 15:1336-1343(2005).
CC   -!- FUNCTION: General factor that plays a role in the activation of
CC       archaeal genes transcribed by RNA polymerase. Binds specifically to the
CC       TATA box promoter element which lies close to the position of
CC       transcription initiation. {ECO:0000255|HAMAP-Rule:MF_00408}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255|HAMAP-
CC       Rule:MF_00408}.
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DR   EMBL; CR936257; CAI48623.1; -; Genomic_DNA.
DR   RefSeq; WP_011322259.1; NC_007426.1.
DR   AlphaFoldDB; Q3ITB1; -.
DR   SMR; Q3ITB1; -.
DR   STRING; 348780.NP_1064A; -.
DR   EnsemblBacteria; CAI48623; CAI48623; NP_1064A.
DR   GeneID; 3703229; -.
DR   KEGG; nph:NP_1064A; -.
DR   eggNOG; arCOG01764; Archaea.
DR   HOGENOM; CLU_060161_4_3_2; -.
DR   OMA; NCEYEPE; -.
DR   OrthoDB; 83880at2157; -.
DR   Proteomes; UP000002698; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   CDD; cd04518; TBP_archaea; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR033711; TBP_archaea.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..187
FT                   /note="TATA-box-binding protein"
FT                   /id="PRO_1000049885"
FT   REPEAT          10..86
FT                   /note="1"
FT   REPEAT          101..179
FT                   /note="2"
SQ   SEQUENCE   187 AA;  20409 MW;  9278561A594715DD CRC64;
     MQDPKETINI ENVVASTGIG QELDLQSVAM DLEGADYDPE QFPGLVYRTQ EPKSAALIFR
     SGKIVCTGAK STDDVHESLR IVFDKLRDLE IQVDEDPEIV VQNIVTSADL GRNLNLNAIA
     IGLGLENIEY EPEQFPGLVY RLDDPDVVAL LFGSGKLVIT GGKEPDDARE AVDKIVSRLE
     ELGLLDG