TBP_PLAFA
ID TBP_PLAFA Reviewed; 228 AA.
AC P32086;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=TATA sequence-binding protein;
DE AltName: Full=TATA-binding factor;
DE AltName: Full=TATA-box factor;
DE AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN Name=TBP;
OS Plasmodium falciparum.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8444340; DOI=10.1016/0378-1119(93)90390-o;
RA McAndrew M.B., Read M., Sims P.F., Hyde J.E.;
RT "Characterisation of the gene encoding an unusually divergent TATA-binding
RT protein (TBP) from the extremely A+T-rich human malaria parasite Plasmodium
RT falciparum.";
RL Gene 124:165-171(1993).
CC -!- FUNCTION: General transcription factor that functions at the core of
CC the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC box is the initial transcriptional step of the pre-initiation complex
CC (PIC), playing a role in the activation of eukaryotic genes transcribed
CC by RNA polymerase II.
CC -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC factors (TAFs). Binds DNA as monomer.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR EMBL; L06060; AAA29769.1; -; Genomic_DNA.
DR PIR; JQ2124; JQ2124.
DR AlphaFoldDB; P32086; -.
DR SMR; P32086; -.
DR EnsemblProtists; CAD51427; CAD51427; PF3D7_0506200.
DR VEuPathDB; PlasmoDB:PF3D7_0506200; -.
DR VEuPathDB; PlasmoDB:Pf7G8-2_000125600; -.
DR VEuPathDB; PlasmoDB:Pf7G8_050011600; -.
DR VEuPathDB; PlasmoDB:PfCD01_050012800; -.
DR VEuPathDB; PlasmoDB:PfDd2_050011300; -.
DR VEuPathDB; PlasmoDB:PfGA01_050010800; -.
DR VEuPathDB; PlasmoDB:PfGB4_050011500; -.
DR VEuPathDB; PlasmoDB:PfGN01_050011200; -.
DR VEuPathDB; PlasmoDB:PfHB3_050011300; -.
DR VEuPathDB; PlasmoDB:PfIT_050011500; -.
DR VEuPathDB; PlasmoDB:PfKE01_050010800; -.
DR VEuPathDB; PlasmoDB:PfKH01_050011800; -.
DR VEuPathDB; PlasmoDB:PfKH02_050011800; -.
DR VEuPathDB; PlasmoDB:PfML01_050011200; -.
DR VEuPathDB; PlasmoDB:PfNF135_050011900; -.
DR VEuPathDB; PlasmoDB:PfNF166_050011500; -.
DR VEuPathDB; PlasmoDB:PfNF54_050010700; -.
DR VEuPathDB; PlasmoDB:PfSD01_050011300; -.
DR VEuPathDB; PlasmoDB:PfSN01_050011600; -.
DR VEuPathDB; PlasmoDB:PfTG01_050011300; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR Gene3D; 3.30.310.10; -; 2.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 1.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Repeat; Transcription.
FT CHAIN 1..228
FT /note="TATA-box-binding protein"
FT /id="PRO_0000153973"
FT REPEAT 52..128
FT /note="1"
FT REPEAT 143..223
FT /note="2"
SQ SEQUENCE 228 AA; 26161 MW; 3D51CC44EEAD4ED5 CRC64;
MNFLEQDQLF LENINQDNVV SAHYTSEYDN NEKEKSDDLK NKLVHKNISL NIHNIISSAN
LCIDINLRLV AVSIRNAEYN PSKINTLIIR LNKPQCTALI FKNGRIMLTG TRTKKDSIMG
CKKIAKIIKI VTKDKVKFCN FKIENIIASA NCNIPIRLEV LAHDHKEYCN YEPELFAGLV
YRYKPTSNLK SVILIFVSGK IIITGCKSVN KLYTVFQDIY NVLIQYKN
