TBP_PROFL
ID TBP_PROFL Reviewed; 300 AA.
AC Q92117;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=TATA sequence-binding protein;
DE AltName: Full=TATA-binding factor;
DE AltName: Full=TATA-box factor;
DE AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN Name=TBP;
OS Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops.
OX NCBI_TaxID=88087;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=7835702; DOI=10.1016/0378-1119(94)00681-h;
RA Nakashima K., Nobuhisa I., Deshimaru M., Ogawa T., Shimohigashi Y.,
RA Fukumaki Y., Hattori M., Sakaki Y., Hattori S., Ohno M.;
RT "Structures of genes encoding TATA box-binding proteins from Trimeresurus
RT gramineus and T. flavoviridis snakes.";
RL Gene 152:209-213(1995).
CC -!- FUNCTION: General transcription factor that functions at the core of
CC the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC box is the initial transcriptional step of the pre-initiation complex
CC (PIC), playing a role in the activation of eukaryotic genes transcribed
CC by RNA polymerase II.
CC -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC factors (TAFs). Binds DNA as monomer. {ECO:0000250|UniProtKB:P20226}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P20226}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR EMBL; D31777; BAA06555.1; -; Genomic_DNA.
DR AlphaFoldDB; Q92117; -.
DR SMR; Q92117; -.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISS:UniProtKB.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Repeat; Transcription.
FT CHAIN 1..300
FT /note="TATA-box-binding protein"
FT /id="PRO_0000153960"
FT REPEAT 126..202
FT /note="1"
FT REPEAT 216..293
FT /note="2"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..110
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 300 AA; 32886 MW; 03A6A9791AE9B4CC CRC64;
MDQNNSLPPY AQGLASPQSA MTPGIPIFSP MMPYGTGLTP QPAQSTNSLS ILEEQQRQQQ
QAAAQQSTSQ PTQAPSGQTP QLFHSQTLTT APLPGTTPLY PSPMTPMTPI TPATPASESS
GIVPQLQNIV STVNLGCKLD LKTIALRARN AEYNPKRFAA VIMRIREPRT TALIFSSGKM
VCTGAKSEEQ SRLAARKYAR VVQKLGFPAK FLDFKIQNMV GSCDVKFPIR LEGLVLTHQQ
FSSYEPELFP GLIYRMIKPR IVLLIFVSGK VVLTGAKVRG EIYEAFENIY PILKGFRKTT
