TBP_SCHPO
ID TBP_SCHPO Reviewed; 231 AA.
AC P17871;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=TATA sequence-binding protein;
DE Short=TBP;
DE AltName: Full=TATA-binding factor;
DE AltName: Full=TATA-box factor;
DE AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN Name=tbp1; Synonyms=tbp, tdf1; ORFNames=SPAC29E6.08, SPAC30.12;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2197558; DOI=10.1038/346291a0;
RA Fikes J.D., Becker D.M., Winston F., Guarente L.;
RT "Striking conservation of TFIID in Schizosaccharomyces pombe and
RT Saccharomyces cerevisiae.";
RL Nature 346:291-294(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=2210373; DOI=10.1101/gad.4.7.1141;
RA Hoffmann A., Horikoshi M., Wang C.K., Schroeder S., Weil P.A., Roeder R.G.;
RT "Cloning of the Schizosaccharomyces pombe TFIID gene reveals a strong
RT conservation of functional domains present in Saccharomyces cerevisiae
RT TFIID.";
RL Genes Dev. 4:1141-1148(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: General transcription factor that functions at the core of
CC the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC box is the initial transcriptional step of the pre-initiation complex
CC (PIC), playing a role in the activation of eukaryotic genes transcribed
CC by RNA polymerase II.
CC -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC factors (TAFs). Binds DNA as monomer.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR EMBL; X53415; CAA37494.1; -; Genomic_DNA.
DR EMBL; Z66525; CAA91430.1; -; Genomic_DNA.
DR EMBL; CU329670; CAB66471.1; -; Genomic_DNA.
DR PIR; A35873; A35873.
DR RefSeq; NP_594566.1; NM_001019995.2.
DR AlphaFoldDB; P17871; -.
DR SMR; P17871; -.
DR BioGRID; 278079; 12.
DR IntAct; P17871; 4.
DR STRING; 4896.SPAC29E6.08.1; -.
DR MaxQB; P17871; -.
DR PaxDb; P17871; -.
DR PRIDE; P17871; -.
DR EnsemblFungi; SPAC29E6.08.1; SPAC29E6.08.1:pep; SPAC29E6.08.
DR GeneID; 2541582; -.
DR KEGG; spo:SPAC29E6.08; -.
DR PomBase; SPAC29E6.08; tbp1.
DR VEuPathDB; FungiDB:SPAC29E6.08; -.
DR eggNOG; KOG3302; Eukaryota.
DR HOGENOM; CLU_060161_4_2_1; -.
DR OMA; NCEYEPE; -.
DR PhylomeDB; P17871; -.
DR Reactome; R-SPO-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-SPO-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-SPO-73772; RNA Polymerase I Promoter Escape.
DR Reactome; R-SPO-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-SPO-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-SPO-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-SPO-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Reactome; R-SPO-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-SPO-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR Reactome; R-SPO-9018519; Estrogen-dependent gene expression.
DR PRO; PR:P17871; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000120; C:RNA polymerase I transcription regulator complex; IDA:PomBase.
DR GO; GO:0005669; C:transcription factor TFIID complex; IDA:PomBase.
DR GO; GO:0000126; C:transcription factor TFIIIB complex; ISO:PomBase.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0001181; F:RNA polymerase I general transcription initiation factor activity; ISO:PomBase.
DR GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:PomBase.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; EXP:PomBase.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISO:PomBase.
DR GO; GO:0001006; F:RNA polymerase III type 3 promoter sequence-specific DNA binding; IDA:PomBase.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR GO; GO:0006361; P:transcription initiation from RNA polymerase I promoter; IDA:PomBase.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISO:PomBase.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; ISO:PomBase.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription.
FT CHAIN 1..231
FT /note="TATA-box-binding protein"
FT /id="PRO_0000153989"
FT REPEAT 58..134
FT /note="1"
FT REPEAT 148..225
FT /note="2"
SQ SEQUENCE 231 AA; 25442 MW; EBFB6D08BA2B6283 CRC64;
MDFALPTTAS QASAFMNNSS LTFPVLPNAN NEATNETADS GDAEVSKNEG VSGIVPTLQN
IVATVNLDCR LDLKTIALHA RNAEYNPKRF AAVIMRIREP KSTALIFASG KMVVLGGKSE
DDSKLASRKY ARIIQKLGFN AKFTDFKIQN IVGSCDVKFP IRLEGLAYSH GTFSSYEPEL
FPGLIYRMVK PKVVLLIFVS GKIVLTGAKV REEIYQAFEA IYPVLSEFRK H
