ID   TBP_SPOFR               Reviewed;         307 AA.
AC   P53361;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=TATA-box-binding protein;
DE   AltName: Full=TATA sequence-binding protein;
DE            Short=TBP;
DE   AltName: Full=TATA-binding factor;
DE   AltName: Full=TATA-box factor;
DE   AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN   Name=Tbp;
OS   Spodoptera frugiperda (Fall armyworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Amphipyrinae; Spodoptera.
OX   NCBI_TaxID=7108;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7520800; DOI=10.1016/0965-1748(94)90057-4;
RA   Rasmussen C., Rohrmann G.F.;
RT   "Characterization of the Spodoptera frugiperda TATA-binding protein:
RT   nucleotide sequence and response to baculovirus infection.";
RL   Insect Biochem. Mol. Biol. 24:699-708(1994).
CC   -!- FUNCTION: General transcription factor that functions at the core of
CC       the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC       box is the initial transcriptional step of the pre-initiation complex
CC       (PIC), playing a role in the activation of eukaryotic genes transcribed
CC       by RNA polymerase II. {ECO:0000250|UniProtKB:P20227}.
CC   -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC       factors (TAFs). Binds DNA as monomer. {ECO:0000250|UniProtKB:P20227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P20226}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; L22538; AAA62394.1; -; mRNA.
DR   AlphaFoldDB; P53361; -.
DR   SMR; P53361; -.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISS:UniProtKB.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR   CDD; cd04516; TBP_eukaryotes; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   InterPro; IPR033710; TBP_eukaryotic.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Repeat; Transcription.
FT   CHAIN           1..307
FT                   /note="TATA-box-binding protein"
FT                   /id="PRO_0000153966"
FT   REPEAT          134..210
FT                   /note="1"
FT   REPEAT          224..301
FT                   /note="2"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  34090 MW;  3979455C6B98A44E CRC64;
     MDQMLPSPYN IPGIDTPLHQ PEEDQQILPN AMQQQHQHQQ QQQQHALAAM GSSPLVGFGA
     SLMGTPQRSV HTYAPAASYA TPQQMMQPQT PQNLMSPMIT SGSLAGQQML SQASPAPMTP
     MTPHSADPGI VPQLQNIVST VNLNCKLDLK KIALHARNAE YNPKRFAAVI MRIREPRTTA
     LIFSSGKMVC TGAKSEEDSR LAARKYARII QKLGFTAKFL DFKIQNMVGS CDVKFPIRLE
     GLVLTHGQFS SYEPELFPGL IYRMVKPRIV LLIFVSGKVV LTGAKVREEI YEAFDNIYPI
     LKSFKKQ