ID   TBP_STRPU               Reviewed;         265 AA.
AC   P91809;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=TATA-box-binding protein;
DE   AltName: Full=TATA sequence-binding protein;
DE            Short=TBP;
DE   AltName: Full=TATA-binding factor;
DE   AltName: Full=TATA-box factor;
DE   AltName: Full=Transcription initiation factor TFIID TBP subunit;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Rybacki L., Childs G.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: General transcription factor that functions at the core of
CC       the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC       box is the initial transcriptional step of the pre-initiation complex
CC       (PIC), playing a role in the activation of eukaryotic genes transcribed
CC       by RNA polymerase II.
CC   -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC       factors (TAFs). Binds DNA as monomer.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U86586; AAB47272.1; -; mRNA.
DR   RefSeq; NP_999786.1; NM_214621.1.
DR   AlphaFoldDB; P91809; -.
DR   SMR; P91809; -.
DR   STRING; 7668.SPU_012621-tr; -.
DR   EnsemblMetazoa; NM_214621; NP_999786; GeneID_373479.
DR   GeneID; 373479; -.
DR   KEGG; spu:373479; -.
DR   CTD; 6908; -.
DR   eggNOG; KOG3302; Eukaryota.
DR   HOGENOM; CLU_060161_4_1_1; -.
DR   OMA; VYRMDEP; -.
DR   OrthoDB; 1219067at2759; -.
DR   PhylomeDB; P91809; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   CDD; cd04516; TBP_eukaryotes; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   InterPro; IPR033710; TBP_eukaryotic.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repeat; Transcription.
FT   CHAIN           1..265
FT                   /note="TATA-box-binding protein"
FT                   /id="PRO_0000153968"
FT   REPEAT          91..167
FT                   /note="1"
FT   REPEAT          181..258
FT                   /note="2"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  29108 MW;  53AED314D2D98926 CRC64;
     MYNPSQAVPV SLHKNQDNQD GGQQRSHYPQ ISSQQSQSYL SVPSIGTPSF GSVGSVSSLA
     PGSSFIPPSP MAPLTPATPA SSESSGIVPQ LQNIVSTVNL NCRLDLKKIA LHARNAEYNP
     KRFAAVIMRI REPRTTALIF SSGKMVCTGA KREDNSRLAA RKYARVVQKL GFAAKFLDFK
     IQNMVGSCDV KFPIRLEGLV LTHGQFSSYE PELFPGLIYR MVKPRIVLLI FVSGKVVLTG
     AKVRQEIYDA FNNIYPILKS FKKTS