TBP_SULAC
ID TBP_SULAC Reviewed; 197 AA.
AC Q9UWN7; Q4J956; Q53648;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=TATA-box-binding protein;
DE AltName: Full=Box A-binding protein;
DE Short=BAP;
DE AltName: Full=TATA sequence-binding protein;
DE Short=TBP;
DE AltName: Full=TATA-box factor;
GN Name=tbp; OrderedLocusNames=Saci_1336;
OS Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS 15157 / NCIMB 11770).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=330779;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Lanzendorfer M., Hain J., Grampp B., Lottspeich F., Zillig W.;
RT "Functional analysis of the TBP-homologous box A binding protein of the
RT extremely thermophilic archaeon Sulfolobus acidocaldarius.";
RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Bell S.D., Jackson S.P.;
RT "The role of TFB in transcription initiation and promoter clearance in the
RT archaeon Sulfolobus acidocaldarius.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT "The genome of Sulfolobus acidocaldarius, a model organism of the
RT Crenarchaeota.";
RL J. Bacteriol. 187:4992-4999(2005).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 2-197.
RX PubMed=14725775; DOI=10.1016/j.str.2003.12.003;
RA Koike H., Kawashima-Ohya Y., Yamasaki T., Clowney L., Katsuya Y.,
RA Suzuki M.;
RT "Origins of protein stability revealed by comparing crystal structures of
RT TATA binding proteins.";
RL Structure 12:157-168(2004).
CC -!- FUNCTION: General factor that plays a role in the activation of
CC archaeal genes transcribed by RNA polymerase. Binds specifically to the
CC TATA box promoter element which lies close to the position of
CC transcription initiation (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAY80671.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA64405.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X94935; CAA64405.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF205428; AAF18138.1; -; Genomic_DNA.
DR EMBL; CP000077; AAY80671.1; ALT_INIT; Genomic_DNA.
DR PDB; 1MP9; X-ray; 2.00 A; A/B=2-197.
DR PDBsum; 1MP9; -.
DR AlphaFoldDB; Q9UWN7; -.
DR SMR; Q9UWN7; -.
DR STRING; 330779.Saci_1336; -.
DR EnsemblBacteria; AAY80671; AAY80671; Saci_1336.
DR KEGG; sai:Saci_1336; -.
DR PATRIC; fig|330779.12.peg.1289; -.
DR eggNOG; arCOG01764; Archaea.
DR HOGENOM; CLU_060161_4_3_2; -.
DR EvolutionaryTrace; Q9UWN7; -.
DR Proteomes; UP000001018; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR CDD; cd04518; TBP_archaea; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR033711; TBP_archaea.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..197
FT /note="TATA-box-binding protein"
FT /id="PRO_0000154024"
FT REPEAT 14..90
FT /note="1"
FT REPEAT 105..181
FT /note="2"
FT STRAND 11..22
FT /evidence="ECO:0007829|PDB:1MP9"
FT HELIX 29..35
FT /evidence="ECO:0007829|PDB:1MP9"
FT TURN 43..45
FT /evidence="ECO:0007829|PDB:1MP9"
FT STRAND 47..53
FT /evidence="ECO:0007829|PDB:1MP9"
FT TURN 54..57
FT /evidence="ECO:0007829|PDB:1MP9"
FT STRAND 58..62
FT /evidence="ECO:0007829|PDB:1MP9"
FT STRAND 66..71
FT /evidence="ECO:0007829|PDB:1MP9"
FT HELIX 76..92
FT /evidence="ECO:0007829|PDB:1MP9"
FT STRAND 102..113
FT /evidence="ECO:0007829|PDB:1MP9"
FT STRAND 115..118
FT /evidence="ECO:0007829|PDB:1MP9"
FT HELIX 120..126
FT /evidence="ECO:0007829|PDB:1MP9"
FT STRAND 127..131
FT /evidence="ECO:0007829|PDB:1MP9"
FT TURN 134..136
FT /evidence="ECO:0007829|PDB:1MP9"
FT STRAND 138..144
FT /evidence="ECO:0007829|PDB:1MP9"
FT TURN 145..148
FT /evidence="ECO:0007829|PDB:1MP9"
FT STRAND 149..153
FT /evidence="ECO:0007829|PDB:1MP9"
FT STRAND 157..166
FT /evidence="ECO:0007829|PDB:1MP9"
FT HELIX 167..183
FT /evidence="ECO:0007829|PDB:1MP9"
SQ SEQUENCE 197 AA; 22325 MW; 187DDF686D4E444B CRC64;
MIPDEIPYKA VVNIENIVAT VTLDQTLDLY AMERSVPNVE YDPDQFPGLI FRLESPKITS
LIFKSGKMVV TGAKSTDELI KAVKRIIKTL KKYGMQLTGK PKIQIQNIVA SANLHVIVNL
DKAAFLLENN MYEPEQFPGL IYRMDEPRVV LLIFSSGKMV ITGAKREDEV HKAVKKIFDK
LVELDCVKPV EEEELEF
