ID   TBP_TETTH               Reviewed;         246 AA.
AC   Q27850;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=TATA-box-binding protein;
DE   AltName: Full=TATA sequence-binding protein;
DE            Short=TBP;
DE   AltName: Full=TATA-binding factor;
DE   AltName: Full=TATA-box factor;
DE   AltName: Full=Transcription initiation factor TFIID TBP subunit;
OS   Tetrahymena thermophila.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=5911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CU428;
RX   PubMed=8264641; DOI=10.1128/mcb.14.1.723-734.1994;
RA   Stargell L.A., Gorovsky M.A.;
RT   "TATA-binding protein and nuclear differentiation in Tetrahymena
RT   thermophila.";
RL   Mol. Cell. Biol. 14:723-734(1994).
CC   -!- FUNCTION: General transcription factor that functions at the core of
CC       the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC       box is the initial transcriptional step of the pre-initiation complex
CC       (PIC), playing a role in the activation of eukaryotic genes transcribed
CC       by RNA polymerase II.
CC   -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC       factors (TAFs). Binds DNA as monomer.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; L16957; AAC14470.1; -; Unassigned_DNA.
DR   PIR; S41473; S41473.
DR   AlphaFoldDB; Q27850; -.
DR   SMR; Q27850; -.
DR   PRIDE; Q27850; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   CDD; cd04516; TBP_eukaryotes; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   InterPro; IPR033710; TBP_eukaryotic.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Repeat; Transcription.
FT   CHAIN           1..246
FT                   /note="TATA-box-binding protein"
FT                   /id="PRO_0000153974"
FT   REPEAT          53..129
FT                   /note="1"
FT   REPEAT          143..220
FT                   /note="2"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   246 AA;  28181 MW;  D877DB7F8AA7287F CRC64;
     MSSDKTSQQT FKLAPNNSVA QSNSIDQNKN KNNILSTIET MDKSISEDLY PKLQNIVSTV
     NLSTKLDLKQ IALRARNAEY NPKRFAAVIM RLRDPKTTAL IFASGKMVCT GAKTEEDSNR
     AARKYAKIIQ KIGFPVQFKD FKIQNIVGST DVKFPINLDH LEQDHKKFVQ YEPEIFPGKI
     YREFNTKIVL LIFVSGKIVL TGAKTRENIN KAFQKIYWVL YNYQKKDYRG ANLHNQNLNI
     KPSIKN