ID   TBP_THEKO               Reviewed;         190 AA.
AC   Q52366;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=TATA-box-binding protein;
DE   AltName: Full=Box A-binding protein;
DE            Short=BAP;
DE   AltName: Full=TATA sequence-binding protein;
DE            Short=TBP;
DE   AltName: Full=TATA-box factor;
GN   Name=tbp; OrderedLocusNames=TK0132;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=8529878; DOI=10.1016/0378-1119(95)00603-2;
RA   Rashid N., Morikawa M., Imanaka T.;
RT   "An abnormally acidic TATA-binding protein from a hyperthermophilic
RT   archaeon.";
RL   Gene 166:139-143(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: General factor that plays a role in the activation of
CC       archaeal genes transcribed by RNA polymerase. Binds specifically to the
CC       TATA box promoter element which lies close to the position of
CC       transcription initiation.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; D50018; BAA08743.1; -; Genomic_DNA.
DR   EMBL; AP006878; BAD84321.1; -; Genomic_DNA.
DR   RefSeq; WP_011249087.1; NC_006624.1.
DR   AlphaFoldDB; Q52366; -.
DR   SMR; Q52366; -.
DR   STRING; 69014.TK0132; -.
DR   EnsemblBacteria; BAD84321; BAD84321; TK0132.
DR   GeneID; 3235820; -.
DR   KEGG; tko:TK0132; -.
DR   PATRIC; fig|69014.16.peg.132; -.
DR   eggNOG; arCOG01764; Archaea.
DR   HOGENOM; CLU_060161_4_3_2; -.
DR   InParanoid; Q52366; -.
DR   OMA; NCEYEPE; -.
DR   OrthoDB; 83880at2157; -.
DR   PhylomeDB; Q52366; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   CDD; cd04518; TBP_archaea; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR033711; TBP_archaea.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..190
FT                   /note="TATA-box-binding protein"
FT                   /id="PRO_0000154021"
FT   REPEAT          11..87
FT                   /note="1"
FT   REPEAT          102..178
FT                   /note="2"
SQ   SEQUENCE   190 AA;  21494 MW;  503115E5B077077D CRC64;
     MVDMSNVKLR IENIVASVDL FTDLNLEKVI EICPSSKYNP EEFPGIICRF DDPKVALLIF
     SSGKLVVTGA KSVDDIKRAV YKLIEMLKKI GAKFTREPQI DIQNMVFSGD IGMEFNLDAV
     ALILPNCEYE PEQFPGVIYR VKEPRAVILL FSSGKIVCSG AKSEQDAWEA VKKLLRELEK
     YGLIEEEEEW