ID   TBP_THESM               Reviewed;         185 AA.
AC   C6A0R1;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=TATA-box-binding protein {ECO:0000255|HAMAP-Rule:MF_00408};
DE   AltName: Full=Box A-binding protein {ECO:0000255|HAMAP-Rule:MF_00408};
DE            Short=BAP {ECO:0000255|HAMAP-Rule:MF_00408};
DE   AltName: Full=TATA sequence-binding protein {ECO:0000255|HAMAP-Rule:MF_00408};
DE            Short=TBP {ECO:0000255|HAMAP-Rule:MF_00408};
DE   AltName: Full=TATA-box factor {ECO:0000255|HAMAP-Rule:MF_00408};
GN   Name=tbp {ECO:0000255|HAMAP-Rule:MF_00408}; OrderedLocusNames=TSIB_0138;
OS   Thermococcus sibiricus (strain DSM 12597 / MM 739).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=604354;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 12597 / MM 739;
RX   PubMed=19447963; DOI=10.1128/aem.00718-09;
RA   Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V.,
RA   Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.;
RT   "Metabolic versatility and indigenous origin of the archaeon Thermococcus
RT   sibiricus, isolated from a siberian oil reservoir, as revealed by genome
RT   analysis.";
RL   Appl. Environ. Microbiol. 75:4580-4588(2009).
CC   -!- FUNCTION: General factor that plays a role in the activation of
CC       archaeal genes transcribed by RNA polymerase. Binds specifically to the
CC       TATA box promoter element which lies close to the position of
CC       transcription initiation. {ECO:0000255|HAMAP-Rule:MF_00408}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255|HAMAP-
CC       Rule:MF_00408}.
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DR   EMBL; CP001463; ACS89206.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6A0R1; -.
DR   SMR; C6A0R1; -.
DR   STRING; 604354.TSIB_0138; -.
DR   EnsemblBacteria; ACS89206; ACS89206; TSIB_0138.
DR   KEGG; tsi:TSIB_0138; -.
DR   eggNOG; arCOG01764; Archaea.
DR   HOGENOM; CLU_060161_4_3_2; -.
DR   OMA; NCEYEPE; -.
DR   Proteomes; UP000009079; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   CDD; cd04518; TBP_archaea; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR033711; TBP_archaea.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..185
FT                   /note="TATA-box-binding protein"
FT                   /id="PRO_1000205961"
FT   REPEAT          8..84
FT                   /note="1"
FT   REPEAT          99..175
FT                   /note="2"
SQ   SEQUENCE   185 AA;  20473 MW;  00F3CFA8C6453C00 CRC64;
     MSNVELRIEN IVASVDLFAS LDLEKVIEIC PHSKYNPEEF PGIICRFDEP KVALLVFSSG
     KLVVTGAKSV DDIQAAVSKL VEMLSKIGTK FGRAPEIDIQ NMVFSGDLKM EFNLDAVALV
     LPNCEYEPEQ FPGVIYRVKD PKAVILLFSS GKIVCSGAKS EHDAWEAVKK LLHELDKYGL
     IEEEA