ID   TBP_TRIGA               Reviewed;         302 AA.
AC   Q92146;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=TATA-box-binding protein;
DE   AltName: Full=TATA sequence-binding protein;
DE   AltName: Full=TATA-binding factor;
DE   AltName: Full=TATA-box factor;
DE   AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN   Name=TBP;
OS   Trimeresurus gramineus (Bamboo pit viper) (Indian green tree viper).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Trimeresurus.
OX   NCBI_TaxID=8767;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver, and Venom gland;
RX   PubMed=7835702; DOI=10.1016/0378-1119(94)00681-h;
RA   Nakashima K., Nobuhisa I., Deshimaru M., Ogawa T., Shimohigashi Y.,
RA   Fukumaki Y., Hattori M., Sakaki Y., Hattori S., Ohno M.;
RT   "Structures of genes encoding TATA box-binding proteins from Trimeresurus
RT   gramineus and T. flavoviridis snakes.";
RL   Gene 152:209-213(1995).
CC   -!- FUNCTION: General transcription factor that functions at the core of
CC       the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC       box is the initial transcriptional step of the pre-initiation complex
CC       (PIC), playing a role in the activation of eukaryotic genes transcribed
CC       by RNA polymerase II.
CC   -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC       factors (TAFs). Binds DNA as monomer. {ECO:0000250|UniProtKB:P20226}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P20226}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D31782; BAA06560.1; -; Genomic_DNA.
DR   EMBL; D31776; BAA06554.1; -; Genomic_DNA.
DR   PIR; JC4059; JC4059.
DR   AlphaFoldDB; Q92146; -.
DR   SMR; Q92146; -.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISS:UniProtKB.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR   CDD; cd04516; TBP_eukaryotes; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   InterPro; IPR033710; TBP_eukaryotic.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Repeat; Transcription.
FT   CHAIN           1..302
FT                   /note="TATA-box-binding protein"
FT                   /id="PRO_0000153961"
FT   REPEAT          128..204
FT                   /note="1"
FT   REPEAT          218..295
FT                   /note="2"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          53..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..97
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..112
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   302 AA;  33142 MW;  575B0CE96DC57AE7 CRC64;
     MDQNNSLPPY AQGLASPQSA MTPGIPIFSP MMPYGTGLTP QPAQSTNSLS ILEEQQRQQQ
     QQQAAAQQST SQPTQAPSGQ TPQLFHSQTL TTAPLPGTTP LYPSPMTPMT PITPATPASE
     SSGIVPQLQN IVSTVNLGCK LDLKTIALRA RNAEYNPKRF AAVIMRIREP RTTALIFSSG
     KMVCTGAKSE EQSRLAARKY ARVVQKLGFP AKFLDFKIQN MVGSCDVKFP IRLEGLVLTH
     QQFSSYEPEL FPGLIYRMIK PRIVLLIFVS GKVVLTGAKV RGEIYEAFEN IYPILKGFRK
     TT