TBP_XENTR
ID TBP_XENTR Reviewed; 297 AA.
AC Q28GG8;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=TATA-box-binding protein {ECO:0000250|UniProtKB:P27633};
DE AltName: Full=TATA sequence-binding protein {ECO:0000250|UniProtKB:P27633};
DE AltName: Full=TATA-binding factor {ECO:0000250|UniProtKB:P27633};
DE AltName: Full=TATA-box factor {ECO:0000250|UniProtKB:P27633};
DE AltName: Full=Transcription initiation factor TFIID TBP subunit {ECO:0000250|UniProtKB:P27633};
GN Name=tbp {ECO:0000312|EMBL:CAJ83650.1};
GN Synonyms=tfiid {ECO:0000250|UniProtKB:P27633}; ORFNames=TEgg042d23.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:CAJ83650.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg {ECO:0000312|EMBL:CAJ83650.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:CAJ83650.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAI60510.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP FUNCTION.
RX PubMed=17703192; DOI=10.1038/sj.emboj.7601822;
RA Jacobi U.G., Akkers R.C., Pierson E.S., Weeks D.L., Dagle J.M.,
RA Veenstra G.J.C.;
RT "TBP paralogs accommodate metazoan- and vertebrate-specific developmental
RT gene regulation.";
RL EMBO J. 26:3900-3909(2007).
CC -!- FUNCTION: General transcription factor that functions at the core of
CC the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC box is the initial transcriptional step of the pre-initiation complex
CC (PIC), playing a role in the activation of eukaryotic genes transcribed
CC by RNA polymerase II. Members of the TBP family are differentially
CC required to regulate transcription and development during early
CC embryogenesis (By similarity). Binds to the promoters of select genes.
CC {ECO:0000250|UniProtKB:P27633, ECO:0000269|PubMed:17703192}.
CC -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC factors (TAFs). Binds DNA as monomer. {ECO:0000250|UniProtKB:P20226}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P20226}.
CC -!- PTM: The N-terminal domain is extensively phosphorylated.
CC {ECO:0000250|UniProtKB:P27633}.
CC -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255}.
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DR EMBL; CR761393; CAJ83650.1; -; mRNA.
DR EMBL; BC160510; AAI60510.1; -; mRNA.
DR RefSeq; NP_001016339.1; NM_001016339.3.
DR RefSeq; XP_012818447.1; XM_012962993.2.
DR AlphaFoldDB; Q28GG8; -.
DR SMR; Q28GG8; -.
DR STRING; 8364.ENSXETP00000018725; -.
DR PaxDb; Q28GG8; -.
DR Ensembl; ENSXETT00000018725; ENSXETP00000018725; ENSXETG00000008556.
DR GeneID; 549093; -.
DR KEGG; xtr:549093; -.
DR CTD; 6908; -.
DR Xenbase; XB-GENE-488470; tbp.
DR eggNOG; KOG3302; Eukaryota.
DR HOGENOM; CLU_060161_1_1_1; -.
DR InParanoid; Q28GG8; -.
DR OrthoDB; 1219067at2759; -.
DR PhylomeDB; Q28GG8; -.
DR Reactome; R-XTR-5250924; B-WICH complex positively regulates rRNA expression.
DR Reactome; R-XTR-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-XTR-73762; RNA Polymerase I Transcription Initiation.
DR Reactome; R-XTR-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-XTR-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR Reactome; R-XTR-9018519; Estrogen-dependent gene expression.
DR Proteomes; UP000008143; Chromosome 5.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000008556; Expressed in egg cell and 13 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISS:UniProtKB.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; ISS:UniProtKB.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR CDD; cd04516; TBP_eukaryotes; 1.
DR Gene3D; 3.30.310.10; -; 2.
DR HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR InterPro; IPR000814; TBP.
DR InterPro; IPR030491; TBP_CS.
DR InterPro; IPR012295; TBP_dom_sf.
DR InterPro; IPR033710; TBP_eukaryotic.
DR PANTHER; PTHR10126; PTHR10126; 1.
DR Pfam; PF00352; TBP; 2.
DR PRINTS; PR00686; TIFACTORIID.
DR PROSITE; PS00351; TFIID; 2.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..297
FT /note="TATA-box-binding protein"
FT /id="PRO_0000348609"
FT REPEAT 123..199
FT /note="1"
FT /evidence="ECO:0000255"
FT REPEAT 213..290
FT /note="2"
FT /evidence="ECO:0000255"
FT REGION 52..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..107
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 297 AA; 32693 MW; 0CBF63B82EEA1A9A CRC64;
MDQNNSIPPF QGLASPQGSL TPGINIFSPL MPYGTGLTPQ PVQTTNSLSI LEEQQRQQQQ
AQQSTSQQGN QGSGQTPQLF HPQTLTTAPL PGNTPLYPSP MTPMTPITPA TPASESSGIV
PQLQNIVSTV NLGCKLDLKT IALRARNAEY NPKRFAAVIM RIREPRTTAL IFSSGKMVCT
GAKSEEQSRL AARKYARVVQ KLGFPAKFLD FKIQNMVGSC DVKFPIRLEG LVLTHQQFSS
YEPELFPGLI YRMIKPRIVL LIFVSGKVVL TGAKVRAEIY EAFENIYPIL KGFRKTT
