ID   TBR1_PATPE              Reviewed;         761 AA.
AC   Q9NL40;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=T-box protein 1;
DE   AltName: Full=T-brain;
DE            Short=Ap-TBR {ECO:0000312|EMBL:BAA93701.1};
GN   Name=tbr1; Synonyms=tbr;
OS   Patiria pectinifera (Starfish) (Asterina pectinifera).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea;
OC   Valvatacea; Valvatida; Asterinidae; Patiria.
OX   NCBI_TaxID=7594;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAA93701.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Gastrula {ECO:0000312|EMBL:BAA93701.1};
RX   PubMed=10831044; DOI=10.1046/j.1440-169x.2000.00481.x;
RA   Shoguchi E., Satoh N., Maruyama Y.K.;
RT   "A starfish homolog of mouse T-brain-1 is expressed in the archenteron of
RT   Asterina pectinifera embryos: possible involvement of two T-box genes in
RT   starfish gastrulation.";
RL   Dev. Growth Differ. 42:61-68(2000).
CC   -!- FUNCTION: Probable transcriptional regulator involved in developmental
CC       processes. {ECO:0000250|UniProtKB:Q64336}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201,
CC       ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expression is first detected in the vegetal plate
CC       of the late blastula 17 hours after fertilization. In early gastrula,
CC       it is expressed in the archenteron. In late gastrula, expression is
CC       detected only in the distal portion of the archenteron and becomes
CC       undetectable by the end of gastrulation. {ECO:0000269|PubMed:10831044}.
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DR   EMBL; AB032259; BAA93701.1; -; mRNA.
DR   AlphaFoldDB; Q9NL40; -.
DR   SMR; Q9NL40; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..761
FT                   /note="T-box protein 1"
FT                   /id="PRO_0000419257"
FT   DNA_BIND        287..456
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          1..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          167..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          496..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          545..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          637..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        496..513
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        545..562
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        580..600
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        659..684
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   761 AA;  83039 MW;  2E308F10727891EC CRC64;
     MLGREFYSNV SHVEQGERYT VSHHGSTEDT RQGGNDDLQN TPARSNASTD YSTQSLSNQA
     GMQPAARRTS MVTEGHVARS QQPLTVNTDF FRGTDQPNAT PHPQADPARY AYDSHFHPNT
     EIANFQTPQM HNYHPYHPNL YHHQYPMHNP SPLHHLQQAR VGQMIYQTDP ANPSGFPQAS
     PSDLSTTSSQ SYYHTGRSSP SVSSSTCSSP VELEDLSVPA KTRPADGFTN LQRTTCPDFS
     IPSTEQCMQE LTPRIRPPSA EQQAPSIGAS PPQEFSKASV FLCNSELWRK FHEHRTEMII
     TKQGRRMFPQ LVFRLSGLNP AAHYNVFVDM VIADPNSWKF QSGKWVATGK SDGVPRATGI
     FKHPDSPNTG EHWMRQDIAF SKLKLTNNRG KDSGYLVINS MHIYQPRIHV LDLTGARVLQ
     THSFPETQFI GVTAYQNTDI TQLKIDHNPF AKGFRDNYDS FATRERLSYV ASLQEQRNRT
     KPVQCTAANA IIPSDTTGFP CQTNPTQRSN GQHEGRPLPM KLIRASEPCS STNLAPACNS
     GSGMSGDAIC SDSAPSSTIR HSPKSIGERE GALPNLGALN NSGHPGSVLD TPPNQSPHGG
     CERSNEKHTP AHKLGEGLGC GMLECGEIPW LNTPPSVCSS DNSNPDLPSA KRLRISPAGS
     GSPSVTSGTS LFTSGSSAAP SPPLLTTAPT AHIAPGLDST LSTEGVVQCS NRSLVMPQPY
     YGVGGSFAYQ NDSHMGYSYM GQTRQGLNLA TSAPYYYQQN N