ID   TBRG1_XENTR             Reviewed;         409 AA.
AC   Q66IH2;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Transforming growth factor beta regulator 1;
GN   Name=tbrg1; ORFNames=TEgg020g14.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a growth inhibitor. May be involved in maintaining
CC       chromosomal stability.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TBRG1 family. {ECO:0000305}.
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DR   EMBL; CR761153; CAJ81813.1; -; mRNA.
DR   EMBL; BC081351; AAH81351.1; -; mRNA.
DR   RefSeq; NP_001008140.1; NM_001008139.1.
DR   RefSeq; XP_012812274.1; XM_012956820.1.
DR   AlphaFoldDB; Q66IH2; -.
DR   SMR; Q66IH2; -.
DR   PaxDb; Q66IH2; -.
DR   PRIDE; Q66IH2; -.
DR   DNASU; 493502; -.
DR   GeneID; 493502; -.
DR   KEGG; xtr:493502; -.
DR   CTD; 84897; -.
DR   Xenbase; XB-GENE-962046; tbrg1.
DR   eggNOG; KOG4443; Eukaryota.
DR   HOGENOM; CLU_037126_0_0_1; -.
DR   InParanoid; Q66IH2; -.
DR   OrthoDB; 1397649at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR   InterPro; IPR003889; FYrich_C.
DR   InterPro; IPR003888; FYrich_N.
DR   InterPro; IPR040092; TBRG1.
DR   PANTHER; PTHR22715; PTHR22715; 1.
DR   Pfam; PF05965; FYRC; 1.
DR   Pfam; PF05964; FYRN; 1.
DR   SMART; SM00542; FYRC; 1.
DR   SMART; SM00541; FYRN; 1.
DR   PROSITE; PS51543; FYRC; 1.
DR   PROSITE; PS51542; FYRN; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Reference proteome.
FT   CHAIN           1..409
FT                   /note="Transforming growth factor beta regulator 1"
FT                   /id="PRO_0000274221"
FT   DOMAIN          179..238
FT                   /note="FYR N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00875"
FT   DOMAIN          239..318
FT                   /note="FYR C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00876"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   409 AA;  45785 MW;  AE40778D848CFCFD CRC64;
     MNHSPATTFS PHSRYQELKV RNKKSTKKSH KEKYRLKCLR LRRVAKDMVF ENAALCDEIA
     RTEDKFIRAK EERRFLLKRL LQLQALSEEE PGTSHNSNVS AGYSVPDMAA MNEGNLDMCY
     SSVLDDGGSC KKVKKDKREK GKENKSEAMK KPSKKKRVTE GTTRKWVQPI ALDPCGRPVF
     PIVLEGLTVY SLGEIISDRA GFHEKVAIYP VGFCSTRVYV GMKNPDQKCL YTCQIKDGGT
     GPQFEIVPDD DPQNSIVASS ADECHSILLQ KISTPLGKRF STPDLAGAYF FGFTHPTIQN
     LIQSCPGARK CTGYQWVKFE VCRAGEEQVP RDICESSASV NFEAFQRQSF ATINNSTALA
     GTLDLPEIHA SHDYISTYQE IFLSHSQLAS GMQHLKSPSN QYSPSRSSE