TBX18_CAEEL
ID TBX18_CAEEL Reviewed; 376 AA.
AC O02073;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=T-box transcription factor 18;
DE AltName: Full=Signal element on autosome protein 1;
GN Name=sea-1 {ECO:0000312|WormBase:F19B10.9};
GN Synonyms=tbx-18 {ECO:0000312|WormBase:F19B10.9};
GN ORFNames=F19B10.9 {ECO:0000312|WormBase:F19B10.9};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16139225; DOI=10.1016/j.devcel.2005.06.009;
RA Powell J.R., Jow M.M., Meyer B.J.;
RT "The T-box transcription factor SEA-1 is an autosomal element of the X:A
RT signal that determines C. elegans sex.";
RL Dev. Cell 9:339-349(2005).
RN [3]
RP FUNCTION.
RX PubMed=21471153; DOI=10.1242/dev.057109;
RA Huang X., Zhang H., Zhang H.;
RT "The zinc-finger protein SEA-2 regulates larval developmental timing and
RT adult lifespan in C. elegans.";
RL Development 138:2059-2068(2011).
RN [4]
RP FUNCTION, AND MUTAGENESIS OF 33-GLN--GLN-376.
RX PubMed=23666922; DOI=10.1101/gad.217026.113;
RA Farboud B., Nix P., Jow M.M., Gladden J.M., Meyer B.J.;
RT "Molecular antagonism between X-chromosome and autosome signals determines
RT nematode sex.";
RL Genes Dev. 27:1159-1178(2013).
CC -!- FUNCTION: Transcriptional regulator involved in developmental processes
CC (PubMed:16139225, PubMed:23666922). Directly binds to the promoter
CC region of the sex-determining factor xol-1 to activate its
CC transcription (PubMed:16139225, PubMed:23666922). Its activation of
CC xol-1 transcription controls sex determination and X chromosome dosage
CC compensation to promote male development (PubMed:23666922). Has a role
CC in the fox-1-sex-1-mediated determination of sexual fate
CC (PubMed:21471153). {ECO:0000269|PubMed:16139225,
CC ECO:0000269|PubMed:21471153, ECO:0000269|PubMed:23666922}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201,
CC ECO:0000269|PubMed:16139225}.
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DR EMBL; BX284602; CCD69699.1; -; Genomic_DNA.
DR PIR; T15166; T15166.
DR RefSeq; NP_494611.1; NM_062210.5.
DR AlphaFoldDB; O02073; -.
DR SMR; O02073; -.
DR BioGRID; 39067; 1.
DR STRING; 6239.F19B10.9; -.
DR PaxDb; O02073; -.
DR EnsemblMetazoa; F19B10.9.1; F19B10.9.1; WBGene00004750.
DR GeneID; 173710; -.
DR KEGG; cel:CELE_F19B10.9; -.
DR UCSC; F19B10.9; c. elegans.
DR CTD; 173710; -.
DR WormBase; F19B10.9; CE09476; WBGene00004750; sea-1.
DR eggNOG; KOG3585; Eukaryota.
DR GeneTree; ENSGT00940000170863; -.
DR HOGENOM; CLU_736161_0_0_1; -.
DR InParanoid; O02073; -.
DR OMA; HAYLRNT; -.
DR OrthoDB; 1841541at2759; -.
DR PhylomeDB; O02073; -.
DR Reactome; R-CEL-2032785; YAP1- and WWTR1 (TAZ)-stimulated gene expression.
DR PRO; PR:O02073; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00004750; Expressed in embryo and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:WormBase.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0042464; P:dosage compensation by hypoactivation of X chromosome; IGI:WormBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007530; P:sex determination; IGI:WormBase.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..376
FT /note="T-box transcription factor 18"
FT /id="PRO_0000184475"
FT DNA_BIND 171..364
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 38..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 33..376
FT /note="Missing: In y356; 92% of hermaphrodites are viable.
FT Increases the hermaphrodite viability of the sex-1 y424
FT mutant from 20% to 51%. Double knockout with the sea-2 y407
FT mutant increases the hermaphrodite viability of the sex-1
FT y424 mutant from 20% to 77%. Double knockout with sea-2
FT y407 increases the hermaphrodite viability of the double
FT fox-1(y303) and sex-1(y263) mutant from 0% to 70%. All
FT males are viable in a sea-2(y426) mutant background. Only
FT 17% of hermaphrodites are viable in a knockout with sea-
FT 2(y426), fox-1(y303) and sex-1(y424). The viability of
FT hermaphrodites is reduced to 11% in a triple xol-1(y9),
FT sex-1(y263) and sdc-2 RNAi mutant background. The viability
FT of hermaphrodites is reduced to 51% in a quadruple sea-
FT 2(y407), xol-1(y9), sex-1(y263) and sdc-2 RNAi mutant
FT background."
FT /evidence="ECO:0000269|PubMed:23666922"
SQ SEQUENCE 376 AA; 42705 MW; 627864FA475D8D07 CRC64;
MDTIININNN NQKYPQSAEE YHKVLCNYFI TLQSAMQSTS RPSSSSPPSL PAVSSELLSS
SFPTNAPESS SRDLAPKQNQ FTINVVLFDE KKKKNPEENL PANGDQLATL RSLMMQINPS
SPPSIPATSP QLPLAESENV PESSSTLKDH KFSLNTMLFN VKKNDAVKIS LANQEQWAKF
HEIGTEMMVF NSGRRLFPLL AYKVSGLDPH KLYCAGVHMI PDSAYKQEYD HDLQQWVNCL
NQKKTIFKPT SEILGRIENG FKLMSLGIDM SDVKIFNIAI RKKTPLQIEK SRKPNLDKTI
EVLIQYKYLP VIKIYELSNS GMEKKEIAQA TFPETSFVTV SIYRNQKIKE MKTLGNKYCR
TDRKQIVMEQ RGELEQ
