ID   TBX19_CANLF             Reviewed;         445 AA.
AC   Q5XNS0;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=T-box transcription factor TBX19 {ECO:0000305};
DE            Short=T-box protein 19;
GN   Name=TBX19 {ECO:0000250|UniProtKB:O60806};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hanson J.M., Mol J.A., Meij B.P.;
RT   "Expression of Tpit in the normal canine pituitary and in corticotroph
RT   adenomas.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator involved in developmental
CC       processes. Can activate POMC gene expression and repress the alpha
CC       glycoprotein subunit and thyroid-stimulating hormone beta promoters (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
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DR   EMBL; AY745240; AAU43787.1; -; mRNA.
DR   RefSeq; NP_001005758.1; NM_001005758.1.
DR   AlphaFoldDB; Q5XNS0; -.
DR   SMR; Q5XNS0; -.
DR   STRING; 9612.ENSCAFP00000022507; -.
DR   PaxDb; Q5XNS0; -.
DR   Ensembl; ENSCAFT00030044144; ENSCAFP00030038522; ENSCAFG00030023780.
DR   Ensembl; ENSCAFT00040002268; ENSCAFP00040001935; ENSCAFG00040001213.
DR   GeneID; 449029; -.
DR   KEGG; cfa:449029; -.
DR   CTD; 9095; -.
DR   eggNOG; KOG3585; Eukaryota.
DR   HOGENOM; CLU_038303_0_0_1; -.
DR   InParanoid; Q5XNS0; -.
DR   OMA; GPHRMVM; -.
DR   OrthoDB; 1201455at2759; -.
DR   TreeFam; TF106341; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0003007; P:heart morphogenesis; IBA:GO_Central.
DR   GO; GO:0001707; P:mesoderm formation; IBA:GO_Central.
DR   GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
DR   GO; GO:0045595; P:regulation of cell differentiation; IEA:Ensembl.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR002070; TF_Brachyury.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00938; BRACHYURY.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..445
FT                   /note="T-box transcription factor TBX19"
FT                   /id="PRO_0000184448"
FT   DNA_BIND        45..218
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
SQ   SEQUENCE   445 AA;  47754 MW;  8414B6A8626F4DC0 CRC64;
     MAMSELGIQK TSDGTVSRLL NVVESELQAG REKGDPTEKQ LQIILEDAPL WQRFKEVTNE
     MIVTKNGRRM FPVLKISVSG LDPNAMYSLL LDFVPTDSHR WKYVNGEWVP AGKPEVSSHS
     CVYIHPDSPN FGAHWMKAPI SFSKVKLTNK LNGGGQIMLN SLHKYEPQVH IVRVGGAHRM
     VMNCSFPETQ FIAVTAYQNE EITALKIKYN PFAKAFLDAK ERNHLKDIPE AVSESQHVAY
     SHLGGWIFSN PDGVCAAGNA NYQYATPLPL SAPHTHHGCE PYPGLRGHRQ APYPSAYMHR
     NHSPSVNLIE SSSNNLQVFS GPDSWTSLSS TPHTSILSVP HTSGPINPGP SPYPCLWTIS
     NSGGGPAGPG PDVHASSPGA FLLGGPAVTS PLSAQAPTSA GVEVLGEPSL TSIAVSTWTA
     VASHPFSGWG GPGGGGHHSP SSLDS