ID   TBX19_CHICK             Reviewed;         397 AA.
AC   P79778;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=T-box transcription factor TBX19 {ECO:0000305};
GN   Name=TBX19 {ECO:0000250|UniProtKB:O60806};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn; TISSUE=Embryo;
RX   PubMed=9053317; DOI=10.1242/dev.124.2.411;
RA   Knezevic V., de Santo R., Mackem S.;
RT   "Two novel chick T-box genes related to mouse Brachyury are expressed in
RT   different, non-overlapping mesodermal domains during gastrulation.";
RL   Development 124:411-419(1997).
CC   -!- FUNCTION: May be involved in the initial formation of the
CC       chordamesoderm.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- DEVELOPMENTAL STAGE: First expressed in the early primitive streak. By
CC       stage 4, in Hensen node, early prechordal plate and notochord. Also
CC       expressed in early development in the neural plate ectoderm immediately
CC       anterior to Hensen node. Expression not detected after stage 10-12.
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DR   EMBL; U67087; AAC60072.1; -; mRNA.
DR   RefSeq; NP_990281.1; NM_204950.1.
DR   AlphaFoldDB; P79778; -.
DR   SMR; P79778; -.
DR   STRING; 9031.ENSGALP00000024551; -.
DR   GeneID; 395793; -.
DR   KEGG; gga:395793; -.
DR   CTD; 9095; -.
DR   VEuPathDB; HostDB:geneid_395793; -.
DR   eggNOG; KOG3585; Eukaryota.
DR   InParanoid; P79778; -.
DR   OrthoDB; 1201455at2759; -.
DR   PhylomeDB; P79778; -.
DR   PRO; PR:P79778; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0003007; P:heart morphogenesis; IBA:GO_Central.
DR   GO; GO:0001707; P:mesoderm formation; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR002070; TF_Brachyury.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 2.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00938; BRACHYURY.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..397
FT                   /note="T-box transcription factor TBX19"
FT                   /id="PRO_0000184463"
FT   DNA_BIND        48..216
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          220..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   397 AA;  43686 MW;  8F137C7D271D393B CRC64;
     MADLGCKKPS DCTVSRLLSV VESELRAGRD KGDPTEKQLQ VVLEDAPLWQ RFREVTNEMI
     VTKNGRRMFP VLKISVSGLD PNAMYSFLLD FAPTDGHRWK YVNGEWVPAG KPEPPNHSCV
     YIHPDSPNFG AHWMKAAISF SKVKLTNKLN GSGQIMLNSL HKYEPQVHIV RVGGPHRMVM
     NCSFPETQFI AVTAYQNEEI TALKIKYNPF AKAFLDAKER NHPKDAPEAA SEGQHMTYSH
     SPQAPHGCER YSALRGHRAA PYPPSYMQRN HSPTVNFFES SSNNLQVFSG HDSWTLPSSP
     HANLLSVPHT KGATSPGPSH YPCLWPVSNS AVSVTNPGSE VNSNTSSMFL RGNVPLPTAS
     SSVQIPLQAT VSGGMETQGE APLVRLADSA WTSSHSF