TBX19_MOUSE
ID TBX19_MOUSE Reviewed; 446 AA.
AC Q99ME7; Q0VBH2;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=T-box transcription factor TBX19 {ECO:0000305};
DE Short=T-box protein 19;
DE AltName: Full=T-box factor, pituitary;
GN Name=Tbx19 {ECO:0000312|MGI:MGI:1891158}; Synonyms=Tpit;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=LAF1;
RX PubMed=11290323; DOI=10.1016/s0092-8674(01)00282-3;
RA Lamolet B., Pulichino A.-M., Lamonerie T., Gauthier Y., Brue T.,
RA Enjalbert A., Drouin J.;
RT "A pituitary cell-restricted T-box factor, Tpit, activates POMC
RT transcription in cooperation with Pitx homeoproteins.";
RL Cell 104:849-859(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=11447259; DOI=10.1073/pnas.141234898;
RA Liu J., Lin C., Gleiberman A., Ohgi K.A., Herman T., Huang H.P., Tsai M.J.,
RA Rosenfeld M.G.;
RT "Tbx19, a tissue-selective regulator of POMC gene expression.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:8674-8679(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcriptional regulator involved in developmental
CC processes. Can activate POMC gene expression and repress the alpha
CC glycoprotein subunit and thyroid-stimulating hormone beta promoters.
CC {ECO:0000269|PubMed:11290323}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
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DR EMBL; AF348321; AAK27153.1; -; mRNA.
DR EMBL; AF345520; AAK64365.1; -; mRNA.
DR EMBL; AK038666; BAC30088.1; -; mRNA.
DR EMBL; BC120635; AAI20636.1; -; mRNA.
DR EMBL; BC137731; AAI37732.1; -; mRNA.
DR CCDS; CCDS15439.1; -.
DR RefSeq; NP_114394.1; NM_032005.4.
DR AlphaFoldDB; Q99ME7; -.
DR SMR; Q99ME7; -.
DR BioGRID; 219993; 1.
DR STRING; 10090.ENSMUSP00000027859; -.
DR iPTMnet; Q99ME7; -.
DR PhosphoSitePlus; Q99ME7; -.
DR PaxDb; Q99ME7; -.
DR PRIDE; Q99ME7; -.
DR Antibodypedia; 1794; 147 antibodies from 22 providers.
DR DNASU; 83993; -.
DR Ensembl; ENSMUST00000027859; ENSMUSP00000027859; ENSMUSG00000026572.
DR GeneID; 83993; -.
DR KEGG; mmu:83993; -.
DR UCSC; uc007diw.1; mouse.
DR CTD; 9095; -.
DR MGI; MGI:1891158; Tbx19.
DR VEuPathDB; HostDB:ENSMUSG00000026572; -.
DR eggNOG; KOG3585; Eukaryota.
DR GeneTree; ENSGT00940000160000; -.
DR InParanoid; Q99ME7; -.
DR OMA; GPHRMVM; -.
DR OrthoDB; 1201455at2759; -.
DR PhylomeDB; Q99ME7; -.
DR TreeFam; TF106341; -.
DR BioGRID-ORCS; 83993; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Tbx19; mouse.
DR PRO; PR:Q99ME7; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q99ME7; protein.
DR Bgee; ENSMUSG00000026572; Expressed in animal zygote and 51 other tissues.
DR ExpressionAtlas; Q99ME7; baseline and differential.
DR Genevisible; Q99ME7; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IMP:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0045165; P:cell fate commitment; IMP:MGI.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0003007; P:heart morphogenesis; IBA:GO_Central.
DR GO; GO:0001707; P:mesoderm formation; IBA:GO_Central.
DR GO; GO:0021983; P:pituitary gland development; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045595; P:regulation of cell differentiation; IMP:MGI.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR002070; TF_Brachyury.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00938; BRACHYURY.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..446
FT /note="T-box transcription factor TBX19"
FT /id="PRO_0000184450"
FT DNA_BIND 43..216
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
SQ SEQUENCE 446 AA; 48037 MW; 9BA0995D30547753 CRC64;
MSELATQKAG EGTVSRLLNV VESELQAGRE KGDPTEKQLQ IILEDAPLWQ RFKEVTNEMI
VTKNGRRMFP VLKISVTGLD PNAMYSLLLD FVRTDSHRWK YVNGEWVPAG KPEVSSHSCV
YIHPDSPNFG AHWMKAPISF SKVKLTNKLN GGGQIMLNSL HKYEPQVHIV RVGGAHRMVM
NCSFPETQFI AVTAYQNEEI TALKIKYNPF AKAFLDAKER NHLKDVPEAI SESQHVTYSH
LGGWILSNPD GVCTAANSNY QYATPLPLPA PHTHHGCEHY AGLRGHRQAP YPSAYMHRNH
SPSVNLIESS SNNLQVFSGP DSWTSLSSTP HASILSVPHS NGPINPGPSP YPCLWTISNG
GGGPVASGSE VHASTSGTIL LGNPAVTSPS SLLPTQATTS AGVEVLGEPS LTSIAVSTWT
AVASHPLPGW GGPGGAGRHS SSSLDS
