ID   TBX1B_XENLA             Reviewed;         463 AA.
AC   Q32NI9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=T-box transcription factor TBX1-B;
DE            Short=T-box protein 1-B;
GN   Name=tbx1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcriptional regulator involved in developmental
CC       processes (By similarity). Binds to the palindromic T site 5'-
CC       TTCACACCTAGGTGTGAA-3' DNA sequence (By similarity). Induces pre-
CC       placodal ectoderm (PPE) gene expression in regions where RIPPLY3 is
CC       absent. Plays a role in the formation of the anteroposterior (AP) axis
CC       during embryonic development; required to establish the posterolateral
CC       border of the pre-placodal ectoderm (PPE) acting downstream of the
CC       retinoic acid receptor (RAR) signaling (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:O43435, ECO:0000250|UniProtKB:P70323}.
CC   -!- FUNCTION: Probable transcriptional regulator involved in developmental
CC       processes (By similarity). Binds to the palindromic T site 5'-
CC       TTCACACCTAGGTGTGAA-3' DNA sequence (By similarity). Is required for
CC       normal development of the pharyngeal arch arteries (By similarity).
CC       {ECO:0000250|UniProtKB:O43435, ECO:0000250|UniProtKB:P70323}.
CC   -!- SUBUNIT: Binds DNA as a dimer (By similarity). Interacts with
CC       dscr6/ripply3. {ECO:0000250, ECO:0000250|UniProtKB:O43435}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- DOMAIN: The C-terminus acts as a transcriptional activation domain.
CC       {ECO:0000250}.
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DR   EMBL; BC108602; AAI08603.1; -; mRNA.
DR   RefSeq; NP_001090144.1; NM_001096675.1.
DR   AlphaFoldDB; Q32NI9; -.
DR   SMR; Q32NI9; -.
DR   PRIDE; Q32NI9; -.
DR   DNASU; 735223; -.
DR   GeneID; 735223; -.
DR   KEGG; xla:735223; -.
DR   CTD; 735223; -.
DR   Xenbase; XB-GENE-478088; tbx1.L.
DR   OMA; HHPMNPA; -.
DR   OrthoDB; 1185429at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 735223; Expressed in internal ear and 16 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
DR   GO; GO:0060788; P:ectodermal placode formation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0050793; P:regulation of developmental process; ISS:UniProtKB.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 2.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..463
FT                   /note="T-box transcription factor TBX1-B"
FT                   /id="PRO_0000262461"
FT   DNA_BIND        119..297
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          39..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          75..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          367..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..406
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   463 AA;  51152 MW;  AD4A964B57263884 CRC64;
     MISAISSPWL TQLSHFCDVA AFTANSLSSL NASGGYHLSP SPGDPYSQHE PHYEPCSASQ
     HSYSFGHACP EPESGASSSS CASSTPGSGS TGSSSGNKAP VKKNPKVANI TVQLEMKALW
     DEFNQLGTEM IVTKAGRRMF PTFQVKIFGM DPMADYMLLM DFVPVDDKRY RYAFHSSSWL
     VAGKADPATP GRVHYHPDSP AKGAQWMKQI VSFDKLKLTN NLLDDNGHII LNSMHRYQPR
     FHVVYVDPRK DSEKYAEENF KTFVFEETRF TAVTAYQNHR ITQLKIASNP FAKGFRDCDP
     EDWPRNHRPG SLPLMNAFAR SRNPVSSPPQ NGSDKDGDGR REYERDASVT PLHGDAAHQQ
     LMSRVLSPSL PVPGGLVPLS TGRPSPPHEL RLDPHSQGSE PLHHHPYKYP TSYDHYLGAK
     TRPAPYPLPS IRGHGYHHHP MNPAAANMYS GAGAPGGYEY GPR